Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-07-01
2008-07-01
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C435S007100
Reexamination Certificate
active
10474778
ABSTRACT:
A method of diagnosing cancer comprising the steps of (i) obtaining a sample containing nucleic acid and/or protein from the patient; and (ii) determining whether the sample contains a level of SCN5A (and optionally also SCN9A) voltage-gated Na+ channel nucleic acid or protein associated with cancer. A method of diagnosing breast cancer comprising the steps of (i) obtaining a sample containing nucleic acid and/or protein from the patient; and (ii) determining whether the sample contains a level of voltage-gated Na+ channel nucleic acid or protein, preferably SCN5A or 5CN9A, associated with cancer. A method of treating cancer comprising the step of administering to the patient an agent which selectively prevents the function of SCN5A (and optionally also SCN9A) voltage-gated Na+ channel. A method of treating breast cancer comprising the step of administering to the patient an agent which selectively prevents the function of a voltage-gated Na+ channel, preferably SCN5A or 5CN9A. Genetic constructs and molecules useful in such methods. The methods and compositions are particularly suited to breast cancer.
REFERENCES:
patent: 5599673 (1997-02-01), Keating et al.
patent: 2006/0166194 (2006-07-01), Djamgoz et al.
patent: WO 02/18637 (2002-03-01), None
Lee et al, J Cell Biochem, 1997, 65:513-526.
Tockman et al., Cancer Res., 1992, 52:2711s-2718s.
Greenbaum et al., Genome Biology, 2003, vol. 4, Issue 9, pp. 117.1-117.8.
Diss et al, FEBS Letters,Expression of Skeletal Muscle-Type Voltage-gated Na+Channel in rat and Human Prostate Cancer Cell Lines, vol. 427, (1998), pp. 5-10.
Fletcher et al, Anesthesiology,Sodium Channel in Human Malignant Hyperthermia, vol. 86, (1997), pp. 1023-1032.
Grant et al, American Journal of Medicine,Molecular Biology of Sodium Channels and Their Role in Cardiac Arrhythmias, vol. 110, (2001), pp. 296-305.
Grimes et al, FEBS Letters,Differential Expression of Voltage-Activated Na+Currents in two Prostatic Tumour Cell Lines: Contribution to Invasivenessin Vitro, vol. 369, (1995), pp. 290-294.
Laniado et al, American Journal of Path,Expression and Functional Analysis of Voltage-Activated Na+Channels in Human Prostate Cancer Cell Lines and Their Contribution to Invasionin Vitro, vol. 4, (1997), pp. 1213-1221.
Smith et al, FEBS Letters,Sodium Channel Protein Expression Enhances the Invasiveness of Rat and Human Prostate Cancer Cells, vol. 423, (1998), pp. 19-24.
Akopian et al, FEBS Letters,Structure and Distribution of a Broadly Expressed Atypical Sodium Channel, vol. 400, (1997), pp. 183-187.
Alekov et al, Journal of Physiology,A Sodium Channel Mutation Cuasing Epilepsy in Man Exhibits Subtle Defects in Fast Inactivation and Activationin Vitro, vol. 529, (2000), pp. 533-539.
Bartolomei et al, Journal of Neurocytology,Changes in the mRNAs Encoding Subtypes I, II and III Sodium Channel Alpha Subunits Following Kainate-Induced Seizures in Rat Brain, vol. 26, (1997), pp. 667-678.
Beckers et al, Genomics,A New Sodium Channel α-Subunit Gene(Scn9a)from Schwann Cells Maps to the Scn1a, Scn2a, Scn3a Cluster of Mouse Chromosome 2, vol. 36, (1997), pp. 202-205.
Belcher et al, Proc. Natl. Academy Science USA,Cloning of a Sodium Channel α Subunit from Rabbit Schwann Cells, vol. 92, (1995), pp. 11034-11038.
Black and Waxman, Develop Neurosci,Sodium Channel Expression: A Dynamic Process in Neurons and Non-Neuronal Cells, vol. 18, (1996), pp. 139-152.
Black et al, Mol Brain Res,Spinal Sensory Neurons Express Multiple Sodium Channel α-Subunit mRNAs, vol. 43, (1996), pp. 117-131.
Black et al, GLIA,Glial Cells Have Heart: rH1 Na+Channel mRNA and Protein in Spinal Cord Astrocytes, vol. 3, (1998), pp. 200-208.
Black et al, Mol Brain Res,Sodium Channel mRNAs in Cultured Spinal Cord Astrocytes: in situ Hybridization in Identified Cell Types, vol. 23, (1994), pp. 235-245.
Blandino et al, Membrane Biol,Voltage-Dependent Sodium Channels in Human Small-Cell Lung Cancer Cells: Role in Action Potentials and Inhibition by Lambert-Eaton Syndrome IgG, vol. 143, (1995), pp. 153-163.
Bonhaus et al, Neuropharmacol,The β1 Sodium Channel Subunit Modifies the Interactions of Neurotoxins and Local Anesthetics with the Rat Brain IIA α Sodium Channel in Isolated Membranes but not in Intact Cells, vol. 35, (1996), pp. 605-613.
Bullman, Hum Mol Genet,Phenotype Variation and Newcomers in Ion Channel Disorders, vol. 6, (1997), pp. 1679-1685.
Burgess et al, Nature Genet,Mutation of a New Sodium Channel Gene, Scn8a, in the Mouse Mutant ‘Motor Endplate Disease’,vol. 10, (1995), pp. 461-465.
Cannon, Mol Neurology (JB Martin, ED) Scientific American Inc., NY,Ion Channel Defects in the Hereditary Myotonias and Periodic Paralyses, (1998), pp. 257-277.
Cannon et al, Pflugers Arch,Modification of the Na+Current Conducted by the Rat Skeletal Muscle α Subunit by Coexpression with a Human β Subunit, vol. 423, (1993), pp. 155-157.
Catalano and Shatz, Science,Activity-Dependent Cortical Target Selection by Thalamic Axons, vol. 281, (1998), pp. 559-562.
Catterall, Neuron,Review from Ionic Currents to Molecular Mechanisms: The Structure and Function of Voltage-Gated Sodium Channels, vol. 26, (2000), pp. 13-25.
Catterall, Ann Rev Biochem,Molecular Properties of Voltage-Sensitive Sodium Channels, vol. 55, (1986), pp. 953-985.
Cohen and Levitt, Circ Rec,Partial Characterization of the rH1 Sodium Channel Protein From Rat Heart Using Subtype-Specific Antibodies, vol. 73, (1993), pp. 735-742.
Cushman et al, Thromb Vasc Biol,Tamoxifen and Cardiac Risk Factors in Healthy Women, vol. 21, (2001), pp. 255-261.
Cuzick et al, The Lancet,Electropotential Measurements as a New Diagnostic Modality for Breast Cancer, vol. 352, (1998), pp. 359-363.
Dawes et al, Visual Neuroscience,Identification of Sodium Channel Subtypes Induced in Cultured Retinal Pigment Epithelium Cells, vol. 12, (1995), pp. 1001-1005.
Dib-Hajj et al, Proc Natl Acad Sci USA,NaN, a Novel Voltage-Gated Na Channel, is expressed Preferentially in Peripheral Sensory Neurons and Down-regulated After Axotomy, vol. 95, (1998), pp. 8963-8968.
Dib-Hajj et al, Proc Natl Acad Sci USA,Down-Regulation of Transcripts for Na Channel α-SNS in Spinal Sensory Neurons Following Axotomy,vol. 93, (1996), pp. 14950-14954.
Dib-Hajj et al, FEBS Letters,Sodium Channel in mRNA in the B104 Neuroblastoma Cell Line, vol. 384, (1996), pp. 78-82.
Dib-Hajj et al, Journal of Neurophysiology,Rescue of α-SNS Sodium Channel Expression in Small Dorsal Root Ganglion Neurons After Axotomy by Nerve Growth Factorin Vivo, vol. 79, (1998), pp. 2668-2676.
Dib-Hajj et al, Genomics,Coding Sequence, Genomic Organization, and Conserved Chromosomal Localization of the Mouse Gene Scn11a Encoding the Sodium Channel NaN, vol. 59, (1999), pp. 309-318.
Diss et al, Prostate,Expression Profiles of Voltage-Gated Na+Channel α-Subunit Genes in Rat and Human Prostate Cancer Cell Lines, vol. 48, (2001), pp. 165-178.
Diss et al, FEBS Letters,Expression of Skeletal Muscle-Type Voltage-Gated Na+Channel in Rat and Human Prostate Cancer Cell Lines, vol. 427, (1998), pp. 5-10.
Donahue et al, Devel Biol,Segregation of Na+-Channel Gene Expression During Neuronal-Glial Branching of a Rat PNS-Derived Stem Cell Line, RT4-AC, vol. 147, (1991), pp. 415-424.
Fjell et al, Mol. Brain Res,Differential Role of GDNF and NGF in the Maintenance of Two TTX-Resistance Sodium Channels in Adult DRG Neurons, vol. 67, (1999), pp. 267-282.
Fozzard and Hanck, Physiological Rev,Structure and Function of Voltage-Dependent Sodium Channels: Comparison of Brain II and Cardiac Isoforms, vol. 76, (1996), pp. 887-926.
Fraser et al, J Physio,Voltage-Gated Na+Channel Activity Contributes to Rodent Prostate Cancer Cell Migrationin Vitro, (1998), pp. 513P, 131P.
Fraser et al, Cell Tissue Res;Tetrodotoxin Suppresses Morphological Enhancement of the Metastatic MAT-LyLu Rat Prostate Cancer Cell Line, vol. 295, (1999), pp. 505-512.
Gellens et al, Proc Natl Acad Sci USA,Primary Structure and Functional Expression of the Human Cardiac Tetradotoxin-Insensitive Voltage-Dependent Sodium Channel, vol. 89, (
Coombes Raoul C.
Diss James K. J.
Djamgoz Mustafa B. A.
Fraser Scott P.
Halvorson Mark
Imperial College Innovations Limited
Mersereau C. G.
Nikolai & Mersereau , P.A.
Yu Misook
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