Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1996-02-15
1998-04-28
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
435 5, 435 6, 435 912, 435 9133, 435 691, 435325, 435366, 435372, 514 44, 424 9321, A61K 4900, C12Q 170, C12Q 168
Patent
active
057441227
ABSTRACT:
The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
REFERENCES:
patent: 4681850 (1987-07-01), Stephenson et al.
patent: 4699877 (1987-10-01), Cline et al.
patent: 4795739 (1989-01-01), Lifson et al.
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4869903 (1989-09-01), Lifson et al.
patent: 4975278 (1990-12-01), Senter et al.
patent: 5177192 (1993-01-01), Pak et al.
patent: 5180816 (1993-01-01), Dean
patent: 5225326 (1993-07-01), Bresser et al.
patent: 5386013 (1995-01-01), Lee et al.
patent: 5445940 (1995-08-01), Brenner et al.
Gura, Science, vol. 270, pp. 575-577, Oct. 27, 1995.
Orkin et al., Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, Dec. 7, 1995.
Coghlan, Focus, vol. 148, pp. 14-15, Nov. 25, 1995.
Brown, "News Media, Researchers `Oversold` Gene Therapy, Advisory Panel Says", The Washington Post, Dec. 8, 1995.
Akira et al., "IL-6 and NF-IL6 in Acute-Phase Response and Viral Infection," Immunol. Reviews (1992) 127:25-50.
Emilie et al., "Interleukine-6 Production in High-Grade B-Lymphomas: Correlation With the Presence of Malignant Immunoblasts in Acquired Immunodeficiency Syndrome and in Human Immunodeficiency Virus-Seronegative Patients," Blood, (1992) vol. 80, No. 2, pp. 498-504.
Herndier et al., "Characterization of a Human Kaposi's Sarcoma Cell Line That Induces Angiogenic Tumors in Animals," AIDS 8:575-581.
McGrath et al., "GLQ223: An inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage," Proc.Natl.Acad.Sci.USA, (Apr. 1989) vol. 86, pp. 2844-2848.
Shiramizu, et al., "Indentification of a Common Clonal Human Immunodeficiency Virus Integration Site in Human Immunodeficiency Virus-associated Lymphomas," Cancer Research, (Apr. 15, 1994), vol. 54, pp. 2069-2072.
Tohyama et al., "Growth Autonomy and Tumorigenicity of Interleukin 6-Dependent B Cells Transfected with Interleukin 6 cDNA," J. Exp. Med. (1990) 171:389-400.
Truper et al., "Single-Cell Analysis of Hodgkin and Reed-Sternberg Cells: Molecular Heterogeneity of Gene Expression and p53 Mutations," Blood (1993) 81:3097-3115.
Woodroofe et al., "Long-Term Consequences of Inteleukin-6 Overexpression in Transgenic Mice," DNA and Cell Biology (1992) 11:587-592.
Marshall, Science, vol. 269, pp. 1050-1055, Aug. 25, 1995.
Anderson, Human Gene Therapy, vol. 5, pp. 281-282, 1994.
Challita & Kohn, Proc. Natl. Acad. Sci., USA, vol. 91, pp. 2567-2571, Mar. 1994.
Jaroff, Time, vol. 148, pp. 24-29, 1996.
Herndier et al., Blood, vol. 79, pp. 1768-1772, 1992.
O'Malley et al., Archives of Otolarlyngology--Head and Neck Surgery, vol. 119, pp. 1100-1107, Oct. 1993.
Herndier Brian
McGrath Michael S.
Shiramizu Bruce
Bozicevic Karl
Chambers Jasemine C.
Schmuck Jill D.
University of California, San Franciso
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