Diagnosis and treatment of a disorder of the gastrointestinal tr

Details Diagnosis and treatment of a disorder of the gastrointestinal tr Diagnosis and treatment of a disorder of the gastrointestinal tr

1993-12-28

1995-04-04

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

435810, 435975, A61K 31445

Patent

active

054038480

ABSTRACT:
Cyproheptadine (4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine) for the treatment of non-ulcerative dyspepsia (NUD), more particularly NUD which is characterized by dysfunction of central 5-HT 1A receptors. Dysfunction of the central 5-HT 1A receptors can be diagnosed by an azaspirodecanedione-induced prolactin response which is distinguishable from that observed in a subject with peptic ulcer disease and/or inflammatory bowel disease. A suitable azaspirodecanedione for inducing the prolactin response is buspirone.

REFERENCES:
patent: 4602043 (1986-07-01), Geho et al.
Reylon et al, (1983) Ind. J. Physiol. Pharmac. 27(4)342-44.
Kennedy et al, (1974) Gastroenterology vol. 66(3)396-492.
D. Hoyer, (1988) Journal of Receptor Research vol. 8(1-4) pp. 59-81.
Van de Kar et al., Neuropharmacology, 28, 299-305, 1989.
Allen et al., Arzneimittel-Forschung, 24, 917-922, 1974.
Yatham et al., The Lancet, 1, No. 8652, 1447-1448, 1989.
Urban et al., Pharmacology Biochemistry & Behavior, 25, 457-462, 1986.
Kilbinger et al., The British Journal of Pharmacol., 85, 529-539, 1985.
Dorland's Illustrated Medical Dictionary (1985) Twenty-Sixth Edition, W. B. Sanders Company, Philadelphia, p. 413.
Carroll, Brit.J.Psychiat. (1982), 140, 292-304.
Coppen et al, Brit.J.Psychiat. (1983), 142, 498-504.
Chaudhary et al, Quarterly Journal of Medicine, New Series XXXI, No. 123, Jul. 1962, 307-322.
Dinan et al, Scandanavian Journal of Gastroenterology, 1990, 25, 541-544.
Dinan et al, Journal of Psychosomatic Research, 1990, 34, 575.
Gershon et al, Psychiatry update vol. II, 1983.
Gomez et al, British Medical Journal, 4 Jun. 1977, 1451-1453.
Jiang et al, Gastroenterology 1988; 95:1265-71.
Klein, Gastroenterology 1988; 95:232-41.
Warner, Annals of Internal Medicine, vol. 59, No. 4., Oct. 1963, 464-476.
Talley et al, Annals of Internal Medicine, vol. 108, No. 6, pp. 865-879, 1988.
DELFIA.TM. Prolactin Kit, LKB (Publisher). Oct. 19, 1986.
Read, 7-13, Scandinavian Journal of Gasteroentrology Supplement (1987).

Affiliated with

Also associated with

Rating

Diagnosis and treatment of a disorder of the gastrointestinal tr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnosis and treatment of a disorder of the gastrointestinal tr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis and treatment of a disorder of the gastrointestinal tr will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2380893