Diagnosis and treatment of a disorder of the gastrointestinal tr

Details Diagnosis and treatment of a disorder of the gastrointestinal tr Diagnosis and treatment of a disorder of the gastrointestinal tr

1990-09-18

1994-06-28

Fay, Zohreh A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

053247388

ABSTRACT:
Cyproheptadine (4-(5H-dibenzo[a,d] cyclohepten-5-ylidene)-1-methylpiperidine) for the treatment of non-ulcerative dyspepsia (NUD), more particularly NUD which is characterised by dysfunction of central 5-HT 1A receptors. Dysfunction of the central 5-HT 1A receptors can be diagnosed by an azaspirodecanedione-induced prolactin response which is distinguishable from that observed in a subject with peptic ulcer disease and/or inflammatory bowel disease. A suitable azaspirodecanedione for inducing the prolactin response is buspirone.

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