Diagnosis and/or therapy of tumours using monoclonal antibodies

Details Diagnosis and/or therapy of tumours using monoclonal antibodies Diagnosis and/or therapy of tumours using monoclonal antibodies

1994-09-21

1999-11-16

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241431, 4241441, 4241551, 435 723, 53038822, G01N 33574, A61K 39395, C07K 1618

Patent

active

059852801

ABSTRACT:
The invention provides compounds for use in the diagnosis and/or therapy of tumors and/or as an immunosuppressant agent selected from the group consisting of antibodies which bind to IL-4 receptors and IL-4 receptor-binding fragments thereof. A preferred such compound is monoclonal antibody MR6 produced by the hybridoma deposited at the European Collection of Animal Cell Cultures with the accession number 88033002. The invention also extends to the use of the compounds for in vitro removal of graft-versus-host reactive T-lymphocytes prior to bone marrow transplantation and to a novel protein of molecular weight 200,000 daltons functioning as a receptor for IL-4.

REFERENCES:
"Elevated Expression of the interleukin 4 receptor in carcinoma: a target for immunotherapy?", Br. J. Cancer (1989) 59, 910-914.
Osband et al., Immunology Today 11:193-195, 1990.
Harris et al. TIBTECH 11:42-44, 1993.
Dillman, Annals of Internal Medicine 111:592-603, 1989.
Hird et al., in Carney et al Eds "Genes and Cancer" John Wiley & Sons Ltd. 1990 pp. 183-189.
Waldman, Science 252:1657-1662, 1991.
De Maagd et al. Immunology 54: 745-754,1985.
Goding, J.W. Monoclonal Antibodies pp. 124-129 Academic Press 1983.

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