Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-09-01
1996-11-19
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 74, 435 795, 435975, 436506, 436518, 514179, G01N 33543, G01N 33564
Patent
active
055761860
ABSTRACT:
A method and assay kit are provided for diagnosing systemic lupus erythematosus by detecting a concentration of anti-EF-1.alpha. antibodies that may be found within a sample of body fluid. The assay employs substantially pure EF-1.alpha. antigen, which is preferably bound to a polystyrene support, and an indicator reagent for detecting and quantifying a quantity of anti-EF-1.alpha. antibody that attaches to the bound antigen. The support and bound antigen are contacted with the fluid sample to allow the formation of an antigen/antibody complex between the support-bound EF-1.alpha. antigen and the anti-EF-1.alpha. antibody. The urine-sample assay has a sensitivity for active SLE of at least about 90%, and a specificity of about 90%.
REFERENCES:
patent: 5385824 (1995-01-01), Hoet et al.
Uchiumi et al.; A Human Autoantibody Specific For a Unique Conserved Region of 28 S Ribosomal RNA Inhibits The Interaction of Elongation Factors 1.alpha. and 2 with Ribosomes; vol. 266, No. 4, Issue of Feb. 5, pp. 2054-2062, 1991; The Journal of Biological Chemistry.
Saunders David
The University of Kansas
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