Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1982-12-30
1985-02-12
Marantz, Sidney
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 4, 435 7, 435213, 435810, 436506, 436509, 436529, 436825, G01N 3352, G01N 3368, G01N 3350
Patent
active
044991860
ABSTRACT:
A method for diagnosis of rheumatoid arthritis and related autoimmune diseases comprises blocking calcium ions contained in a blood sample, effecting hydrolysis of a selected substrate in the presence of .alpha..sub.2 -macroglobulin (.alpha..sub.2 M) from the blood sample, and determining the extent of hydrolysis of the substrate. Preferably, .alpha..sub.2 M in plasma is incubated with a hydrolyzable chromogenic substrate and the liberated chromogen is determined spectrophotometrically. A diagnostic kit is also provided.
REFERENCES:
patent: 4221706 (1980-09-01), Ali
patent: 4314936 (1982-02-01), Yaron
patent: 4402934 (1983-09-01), Teodorescu
Chemical Abstracts I, 91:189040f (1979).
Chemical Abstracts II, 93:234464b (1980).
W. Cullman et al., J. Clin. Chem. Clin. Biochem., 19, 287-290 (1981).
T. Sipos et al., Biochem., 9(14), 2766-2775 (1970).
Ganea Doina
Gaspar Alexander M.
Skosey John L.
Spear Gregory T.
Teodorescu Marius C.
Hill Philip
Marantz Sidney
University of Illinois Board of Trustees
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