Diagnosing autoimmune rheumatoid arthritis by measuring proteoly

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase

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435 4, 435 7, 435213, 435810, 436506, 436509, 436529, 436825, G01N 3352, G01N 3368, G01N 3350

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active

044991860

ABSTRACT:
A method for diagnosis of rheumatoid arthritis and related autoimmune diseases comprises blocking calcium ions contained in a blood sample, effecting hydrolysis of a selected substrate in the presence of .alpha..sub.2 -macroglobulin (.alpha..sub.2 M) from the blood sample, and determining the extent of hydrolysis of the substrate. Preferably, .alpha..sub.2 M in plasma is incubated with a hydrolyzable chromogenic substrate and the liberated chromogen is determined spectrophotometrically. A diagnostic kit is also provided.

REFERENCES:
patent: 4221706 (1980-09-01), Ali
patent: 4314936 (1982-02-01), Yaron
patent: 4402934 (1983-09-01), Teodorescu
Chemical Abstracts I, 91:189040f (1979).
Chemical Abstracts II, 93:234464b (1980).
W. Cullman et al., J. Clin. Chem. Clin. Biochem., 19, 287-290 (1981).
T. Sipos et al., Biochem., 9(14), 2766-2775 (1970).

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