Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1995-06-07
1997-09-09
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 71, 435 792, 435 793, 435 794, 435 795, 435974, 435975, 436516, 530324, 530826, C12Q 170
Patent
active
056655363
ABSTRACT:
Vaccines effective in the inhibition of infection caused by the family of retroviruses, HTLV-III, Human T-Cell Leukemia Virus, LAV, Lymphadenopathy-associated virus, ARV-2, AIDS-Related Virus, (AIDS and AIDS-Related Complex) have been developed from an antisera prepared against thymosin .alpha..sub.1 (T.alpha..sub.1), a thymic hormone, as well as from antisera to synthetic peptide fragments of T.alpha..sub.1 and antisera to synthetic peptide fragments inclusive of amino acid positions 92-109 of the p17 gag core protein of HTLV-III, LAV and ARV-2. In this 18 amino acid primary sequence there is a 44 to 50% homology between the gag protein and T.alpha..sub.1. Immunoglobulin (IgG)-enriched preparations of the T.alpha..sub.1 antisera have enhanced activity in blocking vital replication. A diagnostic test capable of directly detecting the presence of HTLV-III, LAV, ARV-2 and related retroviruses associated with AIDS and ARC is also described.
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Goldstein Allan L.
Wang Su-Sun
Nucker Christine M.
Stucker Jeffrey
Viral Technologies Inc.
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