Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-01-04
1997-09-02
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2621, C07H 1920
Patent
active
056633220
ABSTRACT:
The present invention is directed to diadenosine tetraphosphate (AP4A) tetrasodium salt dodecahydrate crystals represented by the following structure: ##STR1## Compared with the conventional amorphous anhydride of AP4A tetrasodium salt, the AP4A tetrasodium salt dodecahydrate crystals of the present invention have a low hygroscopicity and very stable physical properties. During storage, they are scarcely affected by environmental humidity. Thus, the present crystals can be easily handled as a medicine or a starting material for preparing a medicine, which broadens their application range.
REFERENCES:
patent: 3321463 (1967-05-01), Moffatt
patent: 4886749 (1989-12-01), Dombou et al.
Reiss and Moffatt, "Dismutation Reactions of Nucleoside Polyphosphates. III. The Synthesis of .alpha.,.omega.-Dinucleoside 5'-Polyphosphates," J. Organic Chem., 30, 3381-3387 (Oct. 1965).
Biochemicals--Organic Compounds for Research and Diagnostic Reagents, Catalog from Sigma Chemical Co., St. Louis, MO, 1992, p. 327, col. 2, entry No. D1262 (ammonium salt of 5'-Ado-p.sub.4 -5'-Ado).
Luthje et al.(I), "Diadenosine Tetraphosphate (Ap.sub.3 A) Mediates Human Platelet Aggregation by Liberation of ADP," Biochem. Biophys. Res. Comm., 118(3), 704-709 (1984).
Luthje et al.(II), "Catabolism of Ap.sub.3 A and Ap.sub.4 A in Human Plasma--Purification and Characterization of a Glycoprotein Complex with 5'-Nucleotide Phosphodiesterase Activity," Eur. J. Biochem., 149, 119-127 (1985).
Louie et al., "Diadenosine 5',"'-.sup.p1, .sup.p4 -Tetraphosphate, a Potential Antithrombotic Agent," Thrombosis Res., 49, 557-565 (1988).
Hayashi Mayumi
Katayama Tatsuo
Nakajima Hiroshi
Nishikawa Yoshihiro
Ozaki Masahiro
Crane L. Eric
Kight John
Unitika Ltd.
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