Diadenosine 5', 5'"-p.sup.1, p.sup.4,-tetraphosphate analogs as

Details Diadenosine 5', 5'"-p.sup.1, p.sup.4,-tetraphosphate analogs as Diadenosine 5', 5'"-p.sup.1, p.sup.4,-tetraphosphate analogs as

1988-11-21

1991-09-17

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 48, 514 46, 536 26, 536 27, A61K 3170, C07H 2102

Patent

active

050495500

ABSTRACT:
A component of blood platelets analogues thereof are described. The invention is based on the discovery that this component, a dinucleotide, as well as several of its chemically synthesized analogues, is an effective anti-platelet and antithrombotic agent.

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Hollen, "Metabolism of Diadenosine Tetraphosphate (AP.sub.4 A)", Hoppe-Seyler Z. Physiol. Chem., 365 (1984).
Luthje, J. and A. Ogilvie, "Catobolism of AP.sub.3 A and AP.sub.4 A in Human Plasma", Eur. J. Biochem., 149:119-127 (1985).
Guranowski et al., "Phosphonate Analogs of Diadenosine 5',5'"-P.sup.1,P.sup.4 Tetraphosphate . . . ", Biochemistry, 26:3425-3429 (1987).
Blackburn, G. M. et al., "Synthesis and Resistance to Enzymatic Hydrolysis . . . ", Nucleic Acids Research, 15:6991-7004 (1987).
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Andersson, M., (1989) Int. J. Biochem. 21(7):707-714.
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Chao, F. C. et al., (1984) Biochem. Biophys. Res. Comm. 118(3):704-709.
Luthje, J. et al., (1984) Biochem. Biophys. Res. Comm. 118(3):704-709.
Windholz, M. et al., eds., (1983) The Merck Index 10:1262-1263, "8683. Streptokinase".
Hiroshi, N. et al., (1989) Chem. Abstracts 110(6):392, Abstract 44985u; (1988) Japanese Patent Application (kokai), Publication No. JP 6384556.
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