Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2007-11-02
2010-12-14
Puttlitz, Karl J (Department: 1621)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S440000, C549S366000, C549S405000
Reexamination Certificate
active
07851220
ABSTRACT:
The present invention relates to methods to use non-steroidal ligands in nuclear receptor-based inducible gene expression system to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
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Chortyk Orestes
Hormann Robert Eugene
Meteyer Thomas
Smith Howard
Tice Colin M.
Intrexon Corporation
Puttlitz Karl J
Sterne Kessler Goldstein & Fox P.L.L.C.
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