Diacyl penicillins and methods for their production

Details Diacyl penicillins and methods for their production Diacyl penicillins and methods for their production

1970-12-29

1976-01-27

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07d 9916

Patent

active

039351939

ABSTRACT:
Novel diacyl penicillins of the formula ##EQU1## wherein R is alkyl, cycloalkyl, aryl, aralkyl, phenoxyalkyl, heterocyclic carboxyl excepting isoxazole carboxyl derivatives, or ##SPC1##
In which benzene ring A may optionally be substituted and
B represents a protective group for the amino group, and X is a protective group for the carboxyl group, are produced by reacting a benzyl penicillin ester of the formula ##EQU2## wherein X is as defined above, with a chlorinating agent in the presence of tertiary organic base to obtain an imide chloride group-incorporated compound of the formula ##EQU3## and then reacting the compound of the last-named formula with carboxylate of the formula

REFERENCES:
patent: 3479339 (1969-11-01), Holdrege
patent: 3567709 (1971-03-01), Panina et al.
patent: 3594367 (1971-07-01), Abe et al.
patent: 3668200 (1972-06-01), Abe et al.

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