Diaclhydrazine ligands for modulating the expression of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S292000, C549S214000, C549S366000, C564S150000

Reexamination Certificate

active

10775883

ABSTRACT:
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

REFERENCES:
patent: 4814349 (1989-03-01), Addor et al.
patent: 4906280 (1990-03-01), Sandler et al.
patent: 4950666 (1990-08-01), Peake et al.
patent: 4954655 (1990-09-01), Kelly
patent: 4981784 (1991-01-01), Evans et al.
patent: 4985461 (1991-01-01), Hsu et al.
patent: 5071773 (1991-12-01), Evans et al.
patent: 5075471 (1991-12-01), Michelotti et al.
patent: 5283173 (1994-02-01), Fields et al.
patent: 5358966 (1994-10-01), James, Jr. et al.
patent: 5424333 (1995-06-01), Wing
patent: 5429952 (1995-07-01), Garner et al.
patent: 5482962 (1996-01-01), Hormann
patent: 5514578 (1996-05-01), Hogness et al.
patent: 5530028 (1996-06-01), Lidert et al.
patent: 5880333 (1999-03-01), Goff et al.
patent: 6013836 (2000-01-01), Hsu et al.
patent: 6025483 (2000-02-01), Yanofsky
patent: 6147282 (2000-11-01), Goff et al.
patent: 6245531 (2001-06-01), Hogness et al.
patent: 6265173 (2001-06-01), Evans et al.
patent: 6258603 (2001-07-01), Carlson et al.
patent: 6300488 (2001-10-01), Gage et al.
patent: 2103110 (1994-05-01), None
patent: 1245638 (2000-03-01), None
patent: 1313276 (2001-09-01), None
patent: 19837620 (1999-02-01), None
patent: 0234944 (1987-02-01), None
patent: 0236618 (1987-09-01), None
patent: 0286746 (1988-10-01), None
patent: 0339854 (1989-11-01), None
patent: 0347216 (1989-12-01), None
patent: 0361645 (1990-04-01), None
patent: 0395581 (1990-10-01), None
patent: 0253468 (1991-11-01), None
patent: 0228564 (1992-01-01), None
patent: 0461809 (1994-12-01), None
patent: 0639559 (1995-02-01), None
patent: 0496342 (1996-11-01), None
patent: 0965644 (1999-12-01), None
patent: 2231268 (1990-11-01), None
patent: 62209053 (1987-09-01), None
patent: 62293150 (1987-11-01), None
patent: 02207066 (1990-08-01), None
patent: 03141245 (1991-06-01), None
patent: 03145447 (1991-06-01), None
patent: 04089471 (1992-03-01), None
patent: 04235177 (1992-08-01), None
patent: 05039252 (1993-02-01), None
patent: 06172342 (1994-06-01), None
patent: 06184076 (1994-07-01), None
patent: 08231529 (1996-09-01), None
patent: 08231528 (1996-10-01), None
patent: 09100262 (1997-04-01), None
patent: 2000026423 (2000-01-01), None
Database CAPLUS on STN, Acc. No. 1995:119541, Yanaki et al., JP 06184076 A2 (Jul. 5, 1994) (abstract).
Database CAPLUS on STN, Acc. No. 2000:59128, Tada et al., JP 2000026423 (Jan. 25, 2000) (abstract).
Nakagawa, Yoshiaki et al., Quantitative structure-activity studies of insect growth regulators. XI. Stimulation and inhibition of N-acetylglucosamine incorporation in a cultured integument system by substituted N-tert-butyl-N,N′-dibenzoylhydrazines. Pesticide Science (1995), 43(4), 339-45.
Nakagawa, Yoshiaki et al., Quantitative structure-activity relationships and designed synthesis of larvicidal N,N′-dibenzoyl-N-tert-butylhydrazines against Chila suppressalis. Pesticide Science (1995), 44(1), 102-5.
Le, D. P. et al., RH-2485 A new selective insecticide for caterpillar control. Brighton Crop Protection Conference-- Pests and Diseases (1996), (vol. 2), 481-486.
Carlson, Glenn R. et al., The Chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist. Pest Management Science (2001), 57(2), 115-119.
Nie, Kaisheng et al., New type of insect growth regulator-chromafenozide. Nongyao (2001), 40(2), 42-43.
Cao, S. et al., N′-tert-butyl-N′-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazines, a novel nonsteroidal ecdysone agonist: syntheses, insecticidal activity, conformational, and crystal structure analysis. Canadian Journal of Chemistry (2001), 79(3), 272-278.
Sawada, Yoshihiro et al., Synthesis and insecticidal activity of 3,5-dimethylbenzoyl moiety modified analogues of N-tert-butyl-N′-(4-ethylbenzoyl)-3,5-dimethylbenzohydrazide. Nippon Noyaku Gakkaishi (2002), 27(4), 365-373.
Nakagawa, Yoshiaki et al., Quantitative structure-activity studies of insect growth regulators: XIX. Effects of substituents in the aromatic moiety of dibenzoylhydrazines on larvicidal activity against the beet armyworm Spodoptera exigua. Pest Management Science (2002), 58(2), 131-138.
No, D. et al., “Ecdysone-Inducible Gene Expression in Mammalian Cells and Transgenic Mice,”Proc. Natl. Acad. Sci. USA, vol. 93, pp. 3346-3351, 1996.
Zou, Xia-Juan et al. Synthesis of N-benzoyl-N-tert-butyl-N′-[(1,4-dihydro-6-methyl-4-oxo-1-phenyl-3-pyridazinyl) carbonyl]hydrazines. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2003), 42B(10), 2608-2611.
Lynn M. Riddiford et al., “Ecdysone Receptors and Their Biological Actions”, Vitamins and Hormones, 2000, 60:1-73.
Karen S. Christopherson et al., “Ecdysteroid-dependent regulation of genes in mammalian cells by a Drosophila ecdysone receptor and chimeric transactivators”, Proc. Natl. Acad. Sci. U.S.A., 1992, 89: 6314-6318.
Suhr et al., “High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor” PNAS, 1998;95: 7999-8004.
Kakizawa T et al., “Ligand-dependent Heterodimerization of Thyroid Hormone Receptor and Retinoid X Receptor” 1997, JBC, 272: 38; 23799-23804.
Wing, Keith D. et al., RH 5849, a nonsteroidal ecdysone agonist: effects on a Drosophilla cell line. Science (Washington, DC, United States) (1988), 241(4864), 467-9.
Sawada, Yoshihiro et al., Synthesis and insecticidal activity of benzoheterocyclic analogues of N′-benzoyl-N-(tert-butyl)benzohydrazide: part 2. Introduction of substituents on the benzene rings of the benzoheterocycle moiety. Pest Management Science (2003), 59(1), 36-48.
Sawada, Yoshihiro et al., Synthesis and insecticidal activity of benzoheterocyclic analogues of N′-benzoyl-N-(tert-butyl)benzohydrazide: Part 3. Modification of N-tert-butylhydrazine moiety. Pest Management Science (2003), 59(1), 49-57.
Koelle Mr et al., The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily, Cell, 1991, 67: 59-77.
Belshaw et al., Rational design of orthogonal receptor-ligand combinations. Angewandte Chemie, International Edition in English (1995), 34(19), 2129-32.
Pierce et al., Computational binding studies of orthogonal cyclosporin-cyclophilin pairs. Angewandte Chemie, International Edition in English (1997), 36(13/14), 1466-1469.
Peet et al., Engineering Novel Specificities for Ligand-Activated Transcription in th enucelar Hormone Receptor RXR. Chemistry & Biology, 1998, 5, 1, 13-21.
Holt et al., Functional Expression of Exogenous Proteins in Mammalian Sensory Hair Cells Infected with Adenoviral Vectors. J Neurophysiol. (1999), 81(4), 1881-8.
Sawada, Yoshihiro et al., Synthesis and insecticidal activity of benzoheterocyclic analogues of N′-benzoyl-N-(tert-butyl) benzohydrazide. Part 1. Design of benzoheterocyclic analogues. Pest Management Science (2003), 59(1), 25-35.
Hoppe et al., Adenovirus-Mediated Inducible Gene Expression in Vivo by a Hybrid Ecdysone Receptor. Molecular Therapy (2000) 1(2), 159-164.
Zhang, Xiangning et al., Study on synthesis and bioactivity of new diacylhydrazine IGR JS118. Nongyao (2003), 42 (12), 18-20.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diaclhydrazine ligands for modulating the expression of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diaclhydrazine ligands for modulating the expression of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diaclhydrazine ligands for modulating the expression of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3868574

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.