Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-02
2005-08-02
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S438000, C549S001000, C549S029000, C549S064000, C549S066000, C549S200000, C549S434000, C549S430000
Reexamination Certificate
active
06924276
ABSTRACT:
The invention provides dicarboxylic acid-substituted heteroaryl derivatives of the formulain-line-formulae description="In-line Formulae" end="lead"?G1-(C(R1)R2)n-Q1-B-Q2-(C(R3)R4)m-G2 Iin-line-formulae description="In-line Formulae" end="tail"?or a pharmaceutically acceptable salt thereof, wherein G1, G2, R1, R2, R3, R4, n, m, Q1, Q2, and B are as defined in the specification. The invention compounds are inhibitors of matrix metalloproteinase enzymes, including MMP-13. This invention also provides pharmaceutical compositions and methods of treating diseases mediated by MMP-13, including arthritis, asthma, heart disease, atherosclerosis, and osteoporosis, or a pharmaceutically acceptable salt thereof.
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Patel Sudhaker B.
Pfizer Inc.
Purchase, Jr. Claude F.
Warner-Lambert & Company
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