Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...
Reexamination Certificate
2005-04-21
2009-12-01
Blanchard, David J (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds bacterium or component thereof or substance produced...
C424S133100, C424S136100, C424S164100, C530S387100, C530S387300, C530S388200, C530S388400
Reexamination Certificate
active
07625561
ABSTRACT:
Common oral diseases such as periodontitis and dental caries can be prevented effectively by passive immunization. The present invention provides human single chain Fv (scFv) and diabody antibody fragments based on the binding characteristics of the murine monoclonal antibody Guy's 13. Like the parent antibody, these derivatives bind specifically to SAI/II, the surface adhesin ofStreptococcusand the human diabody derivative is capable of aggregating streptococcal cells, making it a useful candidate therapeutic agent for passive immunization against oral diseases.
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Finnern Ricarda
Fischer Rainer
Blanchard David J
Fraunhofer-Gesellschaft zur Förderung der angewandten Forsc
Licata & Tyrrell P.C.
Ogunbiyi Oluwatosin
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