Diabetogene rad: a type II diabetes specific gene

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435196, 530324, A61K 3846, C12N 916

Patent

active

058914307

ABSTRACT:
Purified DNA including a sequence encoding Diabetogene rad.

REFERENCES:
patent: 5179017 (1993-01-01), Axel et al.
Chavrier et al. Mol. Cell. Biol., 10(12): 6578-6585, Dec. 1990.
Bell et al., "Molecular biology of mammalian glucose transporters" Diabetes Care 13:198-208 (1990).
Bergman, "Toward physiological understanding of glucose tolerance" Diabetes 38:1512-1527 (1989).
Bogardus, "Perspective: does insulin resistance primarily affect skeletal muscle?" Diabetes/Metabolism Reviews 5:527-528 (1989).
Bourey et al., "Effects of altered glucose homeostasis on glucose transporter expression in skeletal muscle of the rat", J. Clin. Invest., 86:542-547 (1990).
Brands et al., "The primary structure of the alpha subunit of human elongation factor 1 structural aspects of guanine nucleotide-binding sites" Eur. J. Biochem. 155(1):167-71 (1986).
Carlson et al., "Isolation and mapping of a polymorphic DNA sequence for Nuc. Acids Res. 16:10403 (1988).
Caro et al., "Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes", Diabetes/Metabolism Reviews 5:665-689 (1989).
Colosia et al., "Induction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase mRNA by refeeding and insulin", J. Biol. Chem. 263:18669-18677 (1988).
DeFronzo, "The triumvirate:.beta.-cell, muscle, liver/a collusion responsible for NIDDM", Diabetes 37:667-845 (1988).
Duguid et al., "Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library" PNAS, USA, 85:5738-5742 (1988).
Ericksson et al., "Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus" N.E.J. Medicine 321:337-343 (1989).
Feng et al., "Effect of diabetes on glutamine synthetase expression in rat skeletal muscles", Amer. J. of Physiology 258:E762-E766 (1990).
Foley, "Mechanisms of impaired insulin action in isolated adipocytes from obese and diabetic subjects" Diabetes/Metabolism reviews 4:487-505 (1988).
Gomez-Foix et al., "Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism" J. Biol. Chem. 267:25129-34 (1992).
Griffiths et al., "Diabetes-induced changes in guanine-nucleotide-regulatory-protein mRNA detected using synthetic oligonucleotide probes", Eur.J. Biochem. 193:367-374 (1990).
Ho et al., "Insulin insensitivity in offspring of parents with type 2 diabetes mellitus" Diabetic Medicine 7:31-34 (1990).
Hollenbeck et al., "Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance", J. Clin. Endocrinology and Metabolism 64:1169-1173 (1987).
Knowler et al., "Diabetes mellitus in the pima Indians: incidence, risk factors and pathogenesis", Diabetes/Metabolism Reviews 6:1-27 (1990).
Leaman et al., "Insulin-like growth factor-I and -II messenger RNA expression in muscle, heart, and liver of streptozotocin-diaetic swine", Endocrinology 126:2850-2857 (1990).
Lillioja et al., "Insulin resistance in pima Indians", Acta Med. Scand. Suppl. 723:103-19 (1987).
Lillioja et al., "In vivo insulin action is familial characteristic in nondiabetic pima Indians", Diabetes 36:1329-1335 (1987).
Liu et al., "Subtractive cloning of a hybrid human endogenous retrovirus and calbindin gene in the prostate cell line PC3", Cancer Research 51:4107-4110 (1991).
Mohn et al., "The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells:comparison with serum-stimulated 3T3 cells . . . ", Molecular/Cellular Biology 11:381-390 (1991).
Mohn et al., Immediate-early gene expression differs between regenerating liver, insulin-stimulated H-35 cells, and mitogen-stimulated BALB/C 3T3 cells, J. Biol. Chem. 265:21914-21921 (1990).
Mueckler, "Family of glucose-transporter genes/implications for glucose homeostasis and diabetes", Diabetes 39:6-11 (1990).
Olefsky et al., "Cellular mechanisms of insulin resistance in non-insulin dependent (Type II) diabetes", Amer. J. Med. 85(suppl 5A):86-105 (1988).
Pedersen et al., "Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM", Diabetes 39:865-870 (1990).
Popovich et al., "Diabetes decreases creatine kinase enzyme activity and mRNA level in the rat heart", Amer. J. Physiology 257:E573-E577 (1989).
Reaven, "Role of insulin resistance in human disease", Diabetes 37:1595-1607 (1988).
Reynet et al, "RAD: a novel member of the RAS-GTPase family over-expressed in muscle to type II diabetic humans" (abstract) J. Cell. Biochem. Suppl. O (18 part A) 143 (1994).
Schweinfest et al., "Subtraction hybridization cDNA libraries from colon carcinoma and hepatic cancer", Genet. Annal. Techn. Appl. 7:64-70 (1990).
Sivitz et al., "Regulation of glucose transporter messenger RNA in insulin-deficient states", Nature 340:72-74 (1989).
Strout et al., "Vanadate treatment of streptozotocin diabetic rats restores expression of the insulin-responsive glucose transporter . . . ", Endocrinology 126:2728-2732 (1990).
Tindall et al., "Fidelity of DNA synthesis by the thermus aquaticus DNA polymerase" Biochemistry 27:6008-6013 (1988).
Travis et al., "Subtractive cloning of complementary DNAs and analysis of messenger RNAs with regional heterogeneous distributions in primate cortex", Neuropharmacology 26:845-854 (1987).
Uetsuki et al., "Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1.alpha", J. Biol. Chem. 264:5791-98 (1989).
Walker et al., "Insulin and glucose-dependent regulation of the glucose transport system in the rat L6 skeleton muscle cell line" J. Biol. Chem. 264:6587-6595 (1989).
Warram et al., "Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents", Am. College of Physicians 113:909-915 (1990).
Yoo et al., Cloning, expression and characterization of the human transcription elongation factor, TFIIS Nuc. Acid Res. 19:1073-79 (1991).
Alexander et al., "Insulin stimulates glyceraldehyde-3-phosphate dehydrogenase gene expression through cis-acting DNA sequences", Proceeding of the National Academy of Sciences, vol. 85, pp. 5092-5096, (1988).
Arner et al., "Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and Type 2 (non-insulin-dependent) diabetes mellitus", Diabetologia, vol. 30, pp. 437-440, (1987).
Arora et al., "Glucose Phosphorylation in Tumor Cells", J. Biol. Chem., vol. 265, No. 11, pp. 6481-6488, (1990).
Baron et al., "Rates and tissue sites of non-insulin-and insulin-mediated glucose uptake in humans", Am. J. Physiol., vol. 255, pp. E769-E774, (1988).
Beck-Nielsen, "Insulin Resistance in Skeletal Muscles of Patients with Diabetes Mellitus", Diabetes/Metabolism Reviews, vol. 5, No. 6, pp. 487-493, (1989).
Beguinot et al., "Differentiation-Dependent Phosphorylation of a 175,000 Molecular Weight Protein in Response to Insulin and Insulin-Like Growth Factor-1 in L6 Skeletal Muscle Cells", Endocrinology, vol. 125, pp. 1599-1605, (1988).
Bell et al., "Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q", Proceedings of the National Academy of Sciences, vol. 88, pp. 1484-1488, (1991).
Bogardus et al., "Correlation between Muscle Glycogen Synthase Activity and In Vivo Insulin Action in Man", J. Clin. Invest., vol. 73, pp. 1185-1190, (1984).
Bogardus et al., "Distribution of In Vivo Insulin Action in Pima Indians as Mixture of Three Normal Distributions", Diabetes, vol. 38, pp. 1423-1432, (1989).
Caro et al., "Insulin Receptor Kinase in Human Skeletal Muscle from Obese Subjects with and without Noninsulin Dependent Diabetes", J. Clin Invest., vol. 79, pp. 1330-1337, (1987).
Daniel et al., "Insulin-Stimulated Entry of Glucose Into Muscle In Vivo as a Major Factor in the Regulation of Blood Glucose", J. Physiol., vol. 247, pp. 273-288, (1975).
Dugail et al., "Adipose-tissue-specific increase in glyceraldehyde-3-phosphate dehydrogenase activity and mRNA amounts in sucking p

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diabetogene rad: a type II diabetes specific gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diabetogene rad: a type II diabetes specific gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diabetogene rad: a type II diabetes specific gene will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1368638

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.