Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-11-23
1994-03-29
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514866, A61K 3135
Patent
active
052985253
ABSTRACT:
This invention provides a method for preventing or treating type I diabetes in a mammal comprising administering the mammal an effective amount of at least one compound of the formula I: ##STR1## The invention also provides pharmaceutical preparations useful for the prevention and/or treatment of type I diabetes comprising an effective amount of at least one compound of the formula previously set forth and a pharmaceutically acceptable carrier.
REFERENCES:
patent: 3799945 (1974-03-01), D'Amico et al.
patent: 4276890 (1981-07-01), Fichera
patent: 4311691 (1982-01-01), Fichera
patent: 4575502 (1986-03-01), Hider et al.
patent: 4665064 (1987-05-01), Hider et al.
patent: 4666927 (1987-05-01), Hider et al.
patent: 4738975 (1988-04-01), Nohara et al.
patent: 4840958 (1989-06-01), Hider et al.
patent: 4912118 (1990-03-01), Hider et al.
patent: 4989870 (1990-02-01), Narutomi et al.
patent: 5158966 (1992-10-01), Lafferty et al.
Chemical Abstracts 97:108781x (1982).
Chemical Abstracts 117:14433q (1992).
Amano, K., et al., Studies on autoimmunity for initiation of B-cell destruction: V:Decrease of macrophage-dependent T lymphocytes and natural killer cytotoxicity in Silica-treated BB rats. Diabetes 39: 590-596, 1990.
Asayama, K., et al., Alloxan-induced free-radical production in isolated cells: Selective effect on islet cells. Diabetes 33: 1008-1011, 1984.
Asayama, K., et al., Chemiluminescence as an index of drug-induced free radical production in pancreatic islets. Diabetes 33: 160-163, 1984.
Bach, J. F., Mechanisms of autoimmunity in insulin-dependent diabetes mellitus. Clin. Exp. Immunol. 72: 1-8, 1988.
Baek, H. S., et al., Direct involvement of macrophages in destruction of .beta.-cells leading to development of diabetes in virus-infected mice. Diabetes 40: 1586-1597, 1991.
Baek, H. S., et al., Role of macrophages in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J. Virology 64: 5708-5715, 1990.
Barrand, M. A., et al., Effects of the pyrones, maltol and ethyl maltol, on iron absorption from the rat small intestine. J. Pharm. Pharmacol. 39: 203-211, 1987.
Bertholf, R., et al., A long-term intravenous Model of aluminum maltol toxicity in rabbits: Tissue distribution, hepatic, renal, and neuronal cytoskeletal changes associated with systemic exposure. Toxicology and App. Pharmacology 98: 58-74, 1989.
Bhathal, P. S., et al., Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone. Experientia 40: 894-896, 1984.
Brennan, T. M., et al., A novel synthesis of maltol and related y-pyrones. Tetrahedron Letters 331-333, 1978.
Brismar, T., Neuropathy-Functional Abnormalities in the BB Rat. Metabolism 32: 112-117, 1983.
Brogren, C-H., BB wistar rat monoclonal autoantibodies. Metabolism 32: Abstracts 165, 1983.
Brown, D. M., et al., Glomerular Manifestations of Diabetes in the BB Rat. Metabolism 32: 131-135, 1983.
Brownscheidle, C. M., et al., The Effects of Maternal Diabetes on Fetal Maturation and Neonatal Health. Metabolism 32: 148-155, 1983.
Cahill, G. F., et al., Insulin-dependent diabetes mellitus: the initial lesion, N. Eng. J. Med. 304: 1454-1455, 1981.
Chawla, R. K., et al., A new synthesis of maltol, J. Org. Chem. 39: 3281-3282, 1974.
Coleman, D. L., Lessons from studies with genetic forms of diabetes in the mouse. Metabolism 32: 162-164, 1983.
Davoren, P. R., The isolation of insulin from a single cat pancreas. Biochem. Biophys. Acta. 63: 150-153, 1962.
Drell, D. W., et al., Multiple immunological abnormalities in patients with type I (insulin-dependent) diabetes mellitus. Diabetologia 30: 132-143, 1987.
Dyrberg, T., et al., Humoral Immunity in the Spontaneously Diabetic BB Rat. Metabolism 32: 87-91, 1983.
Einsenbarth, G. Type I diabetes mellitus: a chronic autoimmune disease. N. Eng. J. Med. 314: 1360-1368, 1986.
Eun, H. M., et al., Role of cyclosporin A in macromolecular synthesis of pancreatic beta cells. Diabetes 36: 952-958, 1987.
Farrar, G., et al, Tissue distribution of gallium following administration of the gallium-maltol complex in the rat: A model for an aluminum-maltol complex of neurotoxicological interest. Fd. Chem. Toxic 26: 523-525, 1988.
Finnegan, M. M., et al., Neutral water-soluble post-transition-metal chelate complexes of medical interest: Aluminum and gallium tris (3-hydroxy-4-pyronates), Inorg. Chem. 26: 2171-2176, 1987.
Gepts, W., Islet morphology in type I diabetes. Behring Inst. Mitt. 75: 39-41, 1984.
Gorsuch, A. N., et al., Evidence for a long prediabetic period in type I (insulin-dependent) diabetes. Lancet, 1363-1365, 1981.
Greene D. A., Metabolic Abnormalities in Diabetic Peripheral Nerve: Relation to Impaired Function. Metabolism 32: 118-123, 1983.
Hales, C. N., et al., Immunoassay of insulin with antibody precipitate. Biochem. J. 88: 137-142, 1963.
Hamet P., et al., Platelets and Vascular Smooth Muscle: Abnormalities of Phosphodiesterase, Aggregation, and Cell Growth in Experimental and Human Diabetes. Metabolism 32: 124-130, 1983.
Han, B. H., et al., Studies of the antioxidant components of Korean Ginseng. Proceedings of the 2nd International Ginseng Symposium, 13-17, 1978.
Han, B. H., et al., Chemical and Biological studies on sedative principle of zizyphus plant. Advances in New Drug Development, 381-390, 1991.
Haskins, K., et al., Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T-cell clone. Science 249: 1433-1436, 1990.
Huber, S. Cytolytic T cells are demonstrated in the spleens of encephalomyocarditis virus infected DBA/2 mice which are lytic to beta cells in vitro. Metabolishm 32: Abstracts 166, 1983.
Ihm, S. H., et al., Studies on autoimmunity for the initiation of beta cell destruction. VII. Evidence for antigenic changes on the beta cells leading to the autoimmune destruction of beta cells in BB rats. Diabetes 40: 269-274, 1991.
Ihm, S. H., et al., Studies on autoimmune mechanism for initiation of beta cell destruction: VI. Macrophages essential for development of beta cell-specific cytotoxic effectors and insulitis in NOD mice. Diabetes 39: 1273-1278, 1990.
Ihm, S. H., et al., Predisposing effect of anti-beta cell autoimmune process in NOD mice on the induction of diabetes by environmental insulitis. Diabetologia 33: 709-712, 1990.
Jackson, R., et al., Lymphocyte Abnormalities in the BB Rat. Metabolish 32: 83-86, 1983.
Katoka, S., et al., Immunological aspects of the nonobese diabetic (NOD) mouse; abnormalities of cellular immunity. Diabetes 32: 247-253, 1983.
Kelsey, S. M., et al., Absorption of low and therapeutic doses of ferric maltol, a novel ferric iron compound, in iron deficient subjects using a single dose iron absorption test. J. of Clin. Phar. and Therapeutics 16: 117-122, 1991.
Ko, I. Y., et al., Studies on autoimmunity for the initiation of beta cell destruction. VIII. Pancreatic beta cell-dependent autoantibody to a 38 kD protein precedes the clinical onset of diabetes in BB rats. Diabetologia 34: 548-554, 1991.
Koevary, S., et al., Passive transfer of diabetes from BB/W to Wistar-Furth rats. J. Clin. Invest. 75: 1904-1907, 1985.
Koevary, S., et al., Passive transfer of diabetes in the BB/W rat. Science 220: 727-728, 1983.
Kontoghiorghes, G., Chelators affecting iron absorption in mice, Arzneim-Forsch./Drug Res. 40: 1332-1335, 1990.
Laupacis, A., et al., Cyclosporin prevents diabetes in BB Wistar rats. Lancet 1: 10-12, 1983.
Lee, K. U., et al., Evidence for initial involvement of macrophage in development of insulitis in NOD mice. Diabetes 37: 989-991, 1988.
Lee, K. U., et al., Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats. Diabetes 37: 1054-1058, 1988.
Lee, K. U., et al., Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages. Diabetologia 31: 400-402, 1988.
Like, A. A., et al., Prevention of diabetes in Biobreeding/Worcester rats with monoclonal antibodies that recognize T-lymphocytes of natural killer cells, J. Exp. Med. 164: 1145-1159, 1986.
Like, A. A., et al., Spontaneous diabetes mellitus in the BB/W rat: Effects of glucocorticoids, cyclosporin-A and antiserum
Kawamura Tomoyuki
Yoon Ji-Won
Schenkman Leonard
University Technologies International Inc.
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