Diabetes control by serotonin

Details Diabetes control by serotonin Diabetes control by serotonin

1986-04-09

1988-08-02

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 436829, 514866, 514893, A61K 3722, A61K 942, B01J 1302

Patent

active

047612878

ABSTRACT:
A discovery that insulin alone does not fully control liver function of glucose uptake, release, and synthesize. A second hormone, serotonin, is released in the portal vein as a function of glucose presence in the gut and portal vein. In the absence of the portal serotonin, the liver will not take up and store glucose, and will, in fact, synthesize more glucose.
Adult onset diabetics generally do not have a lack of natural insulin. Whenever a serotonin deficiency is the lacking control factor, this hormone is supplied by a hepatocyte diected vesicle (HDV) containing serotonin timed to reach the liver with the supply of glucose from a meal.

REFERENCES:
patent: 4377567 (1983-03-01), Geho
patent: 4603044 (1986-07-01), Geho et al.

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