Di(tri-lower alkylstannyl)pyrimidine derivative and a process fo

Details Di(tri-lower alkylstannyl)pyrimidine derivative and a process fo Di(tri-lower alkylstannyl)pyrimidine derivative and a process fo

1981-07-28

1984-05-08

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D23952

Patent

active

044476051

ABSTRACT:
The present invention relates to a novel process for producing pyrimidine nucleosides by a reaction between bis(tri-lower alkylstannyl)-5-halogenouracil and 2-substituted tetrahydrofurane. The novel process of the present invention makes it possible to obtain, depending upon the manner of substitution of tetrahydrofurane residue on two nitrogen atoms N.sub.1 and N.sub.3 of 5-halogenouracil, N.sub.1 -mono-substituted compound, N.sub.3 -mono-substituted compound and N.sub.1,N-di-substituted compound among which the last can be converted by hydrolysis thereof into N.sub.1 -mono-substituted compound. The present invention further relates to novel N.sub.3 -mono-substituted compounds and N.sub.1,N.sub.3 -di-substituted compounds obtained by such process. The present invention still further relates to novel bis-(tri-lower alkylstannyl)-5-halogenouracil used in the present invention as a raw compound.

REFERENCES:
patent: 3284296 (1966-11-01), Freiberg
patent: 3419662 (1968-12-01), Weissenberger
patent: 3446827 (1969-05-01), Schwartz
patent: 3629264 (1971-12-01), Pande
patent: 3912734 (1975-10-01), Giller et al.
patent: 3960864 (1976-06-01), Townsend et al.

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