(Di-tert-butylhydroxyphenyl)thio derivatives and antiarterioschl

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514519, 548252, 558396, 564162, C07D25704, A61K 3141, A61K 3105, C07C14700

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active

049545140

ABSTRACT:
(Di-tert-butylhydroxyphenyl)thio derivatives of the formula: ##STR1## wherein R is cyano, carbamoyl, or 5-tetrazolyl; n is an integer of 2 to 6; provided that when R is cyano, n is not 2; or a pharmaceutically acceptable salt thereof; useful in treating arterioschlerosis, ulcer, inflammation, allergy, or the like.

REFERENCES:
patent: 3337576 (1967-08-01), Buchanan
patent: 4029812 (1977-06-01), Wagner et al.
patent: 4076841 (1978-02-01), Wagner et al.
patent: 4755524 (1988-07-01), Mueller et al.
Chemical Abstracts, vol. 94, No. 5, Feb. 2, 1981, Columbus, Oh., USA.
Mamedov, CH.I., "Synthesis of sulfur-containing derivatives of 2,6-di-tert-butylphenols", p. 528, abstract-No. 94:30 290c & Mater. Nauchn. Konf. Aspir. Akad. Nauk. Az. SSR 1980, 1, 127-131.

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