Di-t-butylphenols substituted by an alkoxy or benzyloxy group or

Details Di-t-butylphenols substituted by an alkoxy or benzyloxy group or Di-t-butylphenols substituted by an alkoxy or benzyloxy group or

1990-06-29

1991-11-19

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558396, 558411, 558423, C07C25532, C07C25537, C07C25550

Patent

active

050668226

ABSTRACT:
Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by an alkoxy or benzyloxy group or a benzylthio group, which alkoxy or benzyloxy group is directly substituted by a tetrazole ring, and which benzylthio group is directly substituted by carboxy or tetrazolyl are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Synthetic intermediates for preparing such compounds are also described.

REFERENCES:
patent: 3674836 (1972-07-01), Creger
patent: 4675334 (1987-06-01), Steggles et al.
patent: 4677113 (1987-06-01), Bell et al.
patent: 4710515 (1987-12-01), Kirk et al.
patent: 4711903 (1987-12-01), Mueller et al.
patent: 4714776 (1987-12-01), Bell et al.
Abstracts for Japanese Application 85-039,262B (Toshiba Pharm KK, published Sep. 5, 1985).
Derwent Abstract 05315B/03, Japanese Unexamined Application (Kokai) J53-141,234 (Toshiba Pharm KK, published Dec. 8, 1978).

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