Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-08-26
1991-04-09
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 18, 530323, 530331, 548408, 548344, 548467, 548550, 544141, 544139, 546112, 546208, 546210, A61K 3702, C07K 502, C07F20954, C07D20712
Patent
active
050065114
ABSTRACT:
Enzyme di- or tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.
REFERENCES:
patent: 4384994 (1983-05-01), Veber et al.
patent: 4478826 (1984-10-01), Veber et al.
Greenlee William J.
Veber Daniel F.
Williams Peter D.
Caruso Charles M.
Daniel Mark R.
Lee Lester L.
Merck & Co. , Inc.
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