Di- or tripeptide renin inhibitors containing lactam conformatio

Details Di- or tripeptide renin inhibitors containing lactam conformatio Di- or tripeptide renin inhibitors containing lactam conformatio

1990-03-07

1991-03-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 540531, 544 582, 544168, 546216, 546243, A61K 3743, C07K 508, C07D27910, C07D26530

Patent

active

050011138

ABSTRACT:
Enzyme di- or tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.

REFERENCES:
patent: 4705846 (1987-11-01), Thaisrivongs

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