Di-enzymatic chewable dentifrice

Details Di-enzymatic chewable dentifrice Di-enzymatic chewable dentifrice

1983-12-08

1986-01-14

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Chewing gum type

424 50, 424 94, A61K 968, A61K 728, A61K 3750

Patent

active

045645191

ABSTRACT:
A di-enzymatic chewable dentifrice is provided which contains an oxidizable substrate and an oxidoreductase enzyme specific to such substrate for producing hydrogen peroxide upon chewing of the dentifrice and further contains a thiocyanate salt and lactoperoxidase for interacting with hydrogen peroxide to produce a hypothiocyanate bacterial inhibitor. The concentration of lactoperoxidase is at least about 2% of the concentration of the oxidoreductase enzyme, in International Units, to thereby limit the ratio of hydrogen peroxide to lactoperoxidase during oral chewing of the dentifrice. An illustrative enzymatic system for this purpose contains glucose, glucose oxidase, potassium thiocyanate and lactoperoxidase.

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