Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-21
2007-08-21
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S119000
Reexamination Certificate
active
10649236
ABSTRACT:
The present invention relates to novel triazolo-pyridines of the formula Iwherein R1is fluoro;s is an integer from two to three;R2is (C3-C6)cycloalkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (C1-C4)alkyl, hydroxy, (C1-C6)alkoxy and (C1-C6)alkyl-(C═O)—O—;or R2is (C1-C6)alkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (C1-C6)alkyl, hydroxy, (C1-C6)alkoxy and (C1-C6)alkyl-(C═O)—O—;with the proviso that said compound of formula I cannot be6-[4-(2,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; or6-[4-(3,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine;to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
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Dombroski Mark A.
Letavic Michael A.
McClure Kim F.
Benson Gregg C.
Forman Frank W.
Morris Patricia L.
Pfizer Inc.
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