Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1997-03-18
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142378, 5142385, 514331, 514634, 540605, 544164, 546223, 564227, 564240, A61K 31415, C07C28100, C07C27700, C07D21156, C07D26530
Patent
active
056123329
ABSTRACT:
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a di- or tri-aminoguanidine capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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Cerami Anthony
Ulrich Peter C.
Wagle Dilip R.
Alteon Inc.
Higel Floyd D.
The Rockefeller University
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