Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-10-17
1996-02-20
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514256, 514319, 514322, 514323, 514324, 514326, 514362, 514363, 514365, 514372, 514396, 514414, 540596, 540597, 540598, 540601, 540603, 540607, 544335, 546193, 546199, 546201, 546202, 546205, 546209, 546210, 548127, 548128, 548205, 548214, 548253, 5483061, 548467, 548468, A61K 31445, C07D40106, C07D20904
Patent
active
054929164
ABSTRACT:
The present invention is directed to certain novel compounds identified as di- and tri-substituted piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R.sub.1, R.sub.4, R.sub.5, A,X,Y, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such di and tri substituted piperidines, pyrrolidines, and hexahydro-1H-azepines as the active ingredient thereof are also disclosed.
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Morriello Gregori J.
Patchett Arthur A.
Yang Lihu
Chang Ceila
Merck & Co. , Inc.
Rose David L.
Thies J. Eric
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