Di-and tri-peptide mimetic compounds for Parkinson's disease

Details Di-and tri-peptide mimetic compounds for Parkinson's disease Di-and tri-peptide mimetic compounds for Parkinson's disease

1996-02-16

1997-11-11

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 562444, 562445, A61K 3805, A61K 3806, C07K 500

Patent

active

056864230

ABSTRACT:
A series of di- and tri-peptide mimetic dopamine prodrugs are synthesized in which D-phenylglycine or D-p-hydroxyphenylglycine is attached as tools for delivery of L-dopa through the intestine via the intestinal dipeptide-mediated carrier transport system. These compounds are found useful as an active ingredient for the treatment of Parkinson's disease.

REFERENCES:
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Nakonteczna et al., Liebiss Ann. Chem. (Oct., 1994) 1055-1058.
Felix et al., J. Med. Chem. vol. 17 No. 4 (1974) 422-426.
Amidon et al., "Absorption of Peptide and Peptidomimetic Drugs", Annu. Rev. Pharmacol. Toxicol. 34;321-341, 1994.
Bai et al., "Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery", Pharmaceutical Research 9:969-978, 1992.
Hu et al., "Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-.alpha.-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, . . . ", Pharmaceutical Research 6:66-70, 1989.

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