Di- and tetrahydroisoquinoline derivatives

Details Di- and tetrahydroisoquinoline derivatives Di- and tetrahydroisoquinoline derivatives

1989-11-27

1992-11-10

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514290, 514294, 514307, 514309, 546 4, 546 5, 546 6, 546 10, 546 23, 546 62, 546 65, 546 79, 546 90, 546 93, 546 94, 546 95, 546 98, 546 99, 546100, 546101, 546110, 546111, 546139, 546141, 546146, 546147, 546148, 546150, 544 60, 544126, 544361, 540542, 540544, 540553, 540575, 540599, A61K 31335, A61K 3147, C07D40500, C07D47104, C07D22104, C07D47106

Patent

active

051623358

ABSTRACT:
The invention relates to new di- and tetrahydroisoquinoline derivatives having interesting cytostatic properties, to the preparation of the said new compounds, and to compositions comprising such a compound as a cytostatically active substance.

REFERENCES:
patent: B571638 (1976-03-01), Yonan
patent: 1437802 (1922-12-01), Hartmann et al.
patent: 3597431 (1971-08-01), Coppola et al.
patent: 3629265 (1971-12-01), Grethe et al.
Mollov and Venkov, Eine neue Methode zur Synthese von 2 -Acyl-1-aryl-1,2,3,4-tetrahydroisochinolinen, Synthesis, vol. 1, pp. 62-63, 1970.
Saxena, A. K. et al., Compounds Acting on the CNS: Part XXI-Synthesis of 2-Substituted 1,3,4,6,11,11.alpha.-Hexahydro-2 (H)pyrazino [1,2-b]-isoquinoline & Corresponding 8,9-Dimethoxy- & 6-Phenyl-8,9-dimethoxy Analogs, Ind. J. of Chem. vol. 13, pp. 230-237. (1980).

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