Di- and tetra-fluoro analogs of squalene as inhibitors of squale

Details Di- and tetra-fluoro analogs of squalene as inhibitors of squale Di- and tetra-fluoro analogs of squalene as inhibitors of squale

1990-03-30

1991-04-30

Evans, J. E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514746, 568 14, 568843, 570136, C07C 1726, C07C 2118, A61K 3135

Patent

active

050118595

ABSTRACT:
This invention relates to certain novel di- and tetra-fluoro analogs of squalene and to their methods of use in lowering plasma cholesterol and in inhibiting squalene epoxidase in patients in need thereof.

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patent: 4455441 (1984-06-01), Prestwich
patent: 4839390 (1989-06-01), Naumann et al.
patent: 4876295 (1989-10-01), Peake
Sen, Stephanie E. et al., J. Med. Chem., 32:2152-2158 (1989).
Ceruti, Maurizio et al., Eur. J. Med. Chem., 22:199-208 (1987).
Hayashi, Sei-ichi et al., Chemistry Letters, Chemical Society of Japan, 983-986 (1979).

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