DHP delayed release preparation

Details DHP delayed release preparation DHP delayed release preparation

1989-04-12

1990-10-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424480, 424470, 424471, 424472, 424479, A61K 936

Patent

active

049667726

ABSTRACT:
A solid medicament preparation having long-lasting action containing a sparingly soluble dihydropyridine active compound of the Formula (I) ##STR1## the preparation having a core-coating construction, the core containing at least one of the above mentioned dihydropyridines in slow-release form, the inner-most coating situated around the core contains no active compound and only dissolves slowly and adjacent to the inner-most coating a rapid release initial dose of the active compound mixed with a polymer.

REFERENCES:
patent: 4267138 (1981-05-01), Dobo et al.
patent: 4309405 (1982-01-01), Guley et al.
patent: 4758437 (1988-07-01), Sonobe et al.
patent: 4765990 (1988-08-01), Sugimoto et al.
patent: 4800084 (1989-01-01), Zerbe
patent: 4808413 (1989-02-01), Joshi et al.
Conte et al., "Press-coated, zero order drug delivery systems," I1 Farmaco, No. 3 (Mar. 1984), pp. 67-75.
Salomon et al., "Sustained release of a water-soluble drug . . .", Pharmazeut. Ind., vol. 41, 1979, pp. 799-802.

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