dft-A gene, diagnostic and therapeutic uses thereof

Details dft-A gene, diagnostic and therapeutic uses thereof dft-A gene, diagnostic and therapeutic uses thereof

1998-05-11

2000-04-25

Hutzell, Paula K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, C07H 2104, C07H 2102

Patent

active

060545712

ABSTRACT:
The present invention relates to a novel gene regulated by FOS and RAS transforming pathways, which is identified as dft-A, and which comprises the sequence set forth in FIG. 3. There is also disclosed the novel dft-A protein and an antibody recognizing same. The present invention also relates to a diagnostic method of identifying dft-A mutations in cancer or other diseases in a biological sample of a patient, which comprises: a) subjecting DNA present in the patient's sample to gene sequencing; and b) comparing the sequenced DNA with the sequence of dft-A gene to identify dft-A mutations. The present invention also relates to a diagnostic method of identifying change in dft-A protein level in cancer or other diseases in a biological sample of a patient, which comprises: a)subjecting the patient's sample to the anti-dft-A antibody to form an antibody-dft-A protein complex; and b) detecting the antibody-dft-A protein complex to determine the dft-A protein level in the biological sample.

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