Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-12-22
1990-03-06
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3144
Patent
active
049066382
ABSTRACT:
A pharmaceutical composition comprises an anti-epileptic drug that does not inhibit, enhance or otherwise modify dextromethorphan binding to the central nervous system dextromethorphan receptor and an effective amount of dextromethorphan to potentiate the anticonvulsant activity of the drug. Other related compounds similar to dextromethorphan which inhibit or enhance dextromethorphan binding to the dextromethorphan site in the brain are also suitable as potentiating agents for the anticonvulsants. A method of treating epilepsy and other convulsions include the steps of introducing to the patient an effective amount of the compound comprising an anti-epileptic drug and potentiating amount of dextromethorphan or one of the related compounds.
REFERENCES:
patent: 4694010 (1987-09-01), Musacchio et al.
Frank C. Tortella and Jose M. Musacchio, Dextromethorphan and Carbetapentane: Centrally Acting Non-Opioid Antitussive Agents With Novel Anticonvulsant Properties, Brain Research, 383(1986)314-318.
John Church, David Lodge and Stephen C. Berry, Differential Effects of Dextrorphan and Levorphanol on the Excitation of Rat Spinal Neurons by Amino Acids, Eur. J. Pharmacol., 111(1985)185-190.
Laurane G. Mendelsohn, Gail A. Kerchner, Vin Kalra, Dennis M. Zimmerman and J. David Leander, Phencyclidine Receptors in Rat Brain Cortex, Biochem. Pharmacol., vol. 33, No. 22, pp. 3529-3535, (1984).
Ferkany John W.
Pontecorvo Michael J.
Friedman Stanley J.
Nova Pharmaceutical Corporation
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