Dextrin hydroxycarboxylato polyiron (III) olated complex and pro

Details Dextrin hydroxycarboxylato polyiron (III) olated complex and pro Dextrin hydroxycarboxylato polyiron (III) olated complex and pro

1976-12-30

1980-02-19

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536103, 536113, A61K 31715, C08B 3702

Patent

active

041894740

ABSTRACT:
The present invention is directed to an iron complex used in treatment of iron-deficiency anemia. The complex is formed by reacting a reactive polyiron (III) olated compound with dextrin and at least one hydroxycarboxylic acid. A dextrin-hydroxycarboxylato-polyiron (III) olated complex is produced. The reaction product contains substantially no free iron. Iron concentration is between about 35 and 47%. The complex can be administered non-orally.
The compound of the subject invention has advantages over prior art compounds. Specifically, the subject complex has a high iron content, is thermally stable, and can be preserved. It may be administered intravenously without accumulating in the blood of an animal or damaging its tissue. No serious side effects result from use of the subject complex.

REFERENCES:
patent: 3086009 (1963-04-01), Zuschek et al.
patent: 3252863 (1966-05-01), Lindvall et al.
patent: 3536696 (1970-10-01), Alsop et al.

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