Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-12-11
2007-12-11
Maier, Leigh C. (Department: 1623)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S402000
Reexamination Certificate
active
10975324
ABSTRACT:
An hemoglobin (Hb)-Dextran (Dx) conjugate having a molecular weight between 50 kd and 500 kD provides a blood substitute that results in acceptable erythrocyte sedimentation rate (ESR) and excretion rate (EXC) values. DxHb conjugates of the invention can be used for a variety of purposes as an alternative to blood.
REFERENCES:
patent: 4064118 (1977-12-01), Wong
patent: 4857636 (1989-08-01), Hsia
Caron, A. et al “The effects of stroma-free and dextran-conjugated hemoglobin . . . ” Artif. Cells Blood Subs. Immob. Biotech. (1999) vol. 27, No. 1, pp. 49-64.
Menu, P. et al “Human hemoglobin conjugated to carboxylate dextran . . . ” Artif. Cells Blood Subs. Immob. Biotech. (1994) vol. 22, No. 3, pp. 543-549.
Bonneaux, F. et al “Fixation of various aldehydic dextrans onto human hemoglobin . . . ” J. Prot. Chem. (1995) vol. 14, No. 1, pp. 1-5.
Tsai Sheung Pun
Wong Jeffrey Tze-Fei
Dextrosang Corporation
Maier Leigh C.
McHale & Slavin P.A.
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