Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1981-12-09
1984-05-01
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
424180, C08B 3702
Patent
active
044463162
ABSTRACT:
A method of preparing a polysaccharide derivative of fibrinolysin which comprises reacting fibrinolysin with dextran dialdehyde having a molecular mass of from 20,000 to 110,000 at a pH of from 8.0 to 9.5 and at a temperature within the range of from 5.degree. to 30.degree. C. with the formation of a covalent bond; the resulting fibrinolysin derivative is reduced with sodium borohydride and isolated.
REFERENCES:
patent: 4020268 (1977-04-01), Nishikawa et al.
patent: 4264766 (1981-04-01), Fischer
Carlin et al., "Chem. Abst.", vol. 92, 1980, pp. 191,171(P).
Carlin et al., "Chem. Abst.", vol. 93, 1980, pp. 218,705(a).
Katsuda et al., "Chem. Abst.", vol. 94, 1981, p. 176(c).
Kardiologiya, Moscow, 1977, No. II, pp. 139-142.
Chazov Evgeny I.
Grinberg Grigory M.
Kleiner Gersh I.
Moskvichev Boris V.
Skuya Agris Z.
Adams Bruce L.
Brown Johnnie R.
Burns Robert E.
Lobato Emmanuel J.
Vsesojuzny Kardiologichesky Nauchny Tsentr
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