Devices for performing ion-capture binding assays

Details Devices for performing ion-capture binding assays Devices for performing ion-capture binding assays

1995-05-08

1997-09-23

Spiegel, Carol A.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 792, 435 793, 435 794, 435 795, 435970, 435971, 436529, 436536, 436538, 436540, 436541, 436808, 436810, G01N 3353

Patent

active

056703813

ABSTRACT:
This invention presents novel assay devices employing capture reagents, involving a specific binding member attached to a charged substance, and porous material containing a capture or reaction zone that is oppositely charged with respect to the charged substance included in the capture reagent. In one embodiment, a test sample suspected of containing the analyte of interest is contacted with the capture reagent to form a charged capture reagent/analyte complex. The complex is then contacted to the oppositely charged capture or reaction zone to attract, attach, and immobilize the capture reagent/analyte complex. With an appropriate indicator reagent, both sandwich and competitive assays can be performed.

REFERENCES:
patent: 4948726 (1990-08-01), Longoria
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patent: 5206136 (1993-04-01), Monji et al.
patent: 5459078 (1995-10-01), Kline et al.
patent: 5459080 (1995-10-01), Adamczyk et al.
J.F. Delagneau, et al., "Criteria for the selection of a solid phase to be used in immunoassays", Annales de Biologie clinique, vol. 48, No. 7 (1990), p. 467-471.

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