Devices comprising chondrogenic protein and methods of inducing

Details Devices comprising chondrogenic protein and methods of inducing Devices comprising chondrogenic protein and methods of inducing

1995-05-24

1999-09-28

Kemmerer, Elizabeth C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424426, 514 2, 514 12, 514 21, 530350, 530395, 435691, 4351723, A61K 900, A61K 3818

Patent

active

059584416

ABSTRACT:
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.

REFERENCES:
patent: 4172128 (1979-10-01), Thiele et al.
patent: 4294753 (1981-10-01), Urist
patent: 4394370 (1983-07-01), Jefferies
patent: 4434094 (1984-02-01), Sevedin et al.
patent: 4455256 (1984-06-01), Urist
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563489 (1986-01-01), Urist
patent: 4657548 (1987-04-01), Nichols
patent: 4703108 (1987-10-01), Silver et al.
patent: 4725671 (1988-02-01), Chu et al.
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4789663 (1988-12-01), Wallace et al.
patent: 4795467 (1989-01-01), Piez et al.
patent: 4804744 (1989-02-01), Sen
patent: 4810691 (1989-03-01), Seyedin et al.
patent: 4812120 (1989-03-01), Flanagan et al.
patent: 4824939 (1989-04-01), Simpson
patent: 4837285 (1989-06-01), Bero et al.
patent: 4843063 (1989-06-01), Seyedin et al.
patent: 4877864 (1989-10-01), Wang et al.
patent: 4894441 (1990-01-01), Menicagli
patent: 5013649 (1991-05-01), Wang et al.
patent: 5106626 (1992-04-01), Parsons et al.
patent: 5106748 (1992-04-01), Wozney et al.
patent: 5108922 (1992-04-01), Wang et al.
patent: 5116738 (1992-05-01), Wang et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5166058 (1992-11-01), Wang et al.
patent: 5187076 (1993-02-01), Wozney et al.
Canalis et al., Science 210:1021-1023 (1980).
Glowacki et al., Lancet 1:959-963 (1981).
Reddi, Collagen Rel. Res. 1:209-226 (1981).
Sampath et al. Proc. Natl. Acad. Sci. USA 78:7599-7603 (1981).
Farley et al., Biochem. 21:3508-3513 (1982).
Maugh et al., Science 217:819 (1982).
Sampath et al., Proc. Natl. Acad. Sci. USA 80:6591-6595 (1983).
Seyedin et al., J. Cell Biol. 17:1950-1953 (1983).
Urist et al., Proc. Soc. Exp. Bio. Med. 173:194-199 (1983).
Simpson et al., Trends Biochem. Sci. 9:527-530 (1984).
Strand et al., Biotech. Boeing. 26:503-507 (1984).
Urist et al., Clin. Orth. Rel. Res., 187:277-280 (1984).
Urist et al. II. Proc. Natl. Acad. Sci. USA 81:371-375 (1984).
Centrella et al., Proc. Natl. Acad. Sci. USA 82:7335-7339 (1985).
Klausner, Biotechnology 3:567-568 (1985).
Olson et al., Analyt. Biochem. 146:232-237 (1985).
Reddi, J., Biomed. Mat., Res. 19:233-239 (1985).
Sampath et al., Extracelluler Matrix: Structure and Function (A.H. Reddi, Ed.) Allen R. Liss. Pub., NY, pp. 412-428 (1985).
Seyedin et al., Proc. Natl. Acad. Sci. USA 82:2267-2271 (1985).
Colowick et al., Methods in Enzymology 146:294-312 (1987).
Deatherage et al., Collagen Rel. Res. 7:225-231 (1987).
Padgett et al., Nature 325:81-84 (1987).
Sampath et al., Proc. Natl. Acad. Sci. USA 84:7109-7113 (1987).
Spector, J. Anthroplasty 2:163-177 (1987).
Weeks et al., Cell 51:861-867 (1987).
Aspenberg et al., J. Bone Joint Surg. 70:625-627 (1988).
Bendig, Genetic Engineering 7:91-121 (1988).
Cook et al., Clin. Orthopaed. Rel. Res. 232:225-243 (1988).
Deatherage et al., Int. J. Oral Macillofac. Surg. 17:395-399 (1988).
LeGendre et al., Biotechniques 6:154-159 (1988).
Sedivy, Bio/Technology 6:1192-1196 (1988).
Wang et al., Calcified Tissue Int. (Supplement) Abs. No. 146, p. A37 (1988).
Wang et al., II, Proc. Natl. Acad. Sci. USA 85:9484-9488 (1988).
Wozney et al., Calcified Tissue Int. (Supplement) Abs. No. 147, p. A37 (1988).
Wozney et al., II, Science 242:1528-1534.
Lyons et al, Proc. Natl. Acad. Sci. USA 86:4554-4588 (1989).
Wang et al., PNAS 87:2220-2224 (1990).

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