Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1997-08-19
1999-12-28
Chin, Christopher L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
422 56, 422 58, 422 61, 422101, 435 2, 435 4, 435 71, 435 792, 4352871, 4352872, 4352877, 4352878, 4352879, 435805, 435810, 435962, 435970, 436514, 436169, 436170, 436177, 436178, 436808, 436810, G01N 33543, G01N 33558
Patent
active
060080590
ABSTRACT:
A device for the separation of the liquid portion of blood from the cellular components of blood comprises: (1) a pad of porous material permeable to the liquid portion of blood but capable of trapping the cellular components of blood; (2) a substrate supporting the pad; and (3) means, attached to the pad, for facilitating the flow of the liquid portion of the blood: (i) through interstices around the trapped cellular components of the blood and (ii) from the pad of porous material. The separation of the liquid portion of blood from the cellular components of the blood occurs by flow through the pad of porous material without significant hemolysis. The device can be incorporated into a device for the performance of specific binding assays such as immunoassays. The pad of porous material can contain an agglutinating agent such as a lectin or an anti-blood cell antibody, or a carbohydrate such as mannitol. Other devices and methods for the separation of the liquid portion of blood from the cellular components of the blood are also disclosed.
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Jaseph Corey L.
Ruggeri Franco
Schoengold Ronald J.
Schrier Wayne H.
Beckman Coulter Inc.
Chin Christopher L.
Kivinski Margaret A.
May William H.
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