Devices and methods for pharmacokinetic-based cell culture...

Details Devices and methods for pharmacokinetic-based cell culture... Devices and methods for pharmacokinetic-based cell culture...

2006-09-08

2011-10-04

Beisner, William H (Department: 1775)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S373000, C435S293100, C435S294100

Reexamination Certificate

active

08030061

ABSTRACT:
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

REFERENCES:
patent: 3941662 (1976-03-01), Munder et al.
patent: 3948732 (1976-04-01), Haddad et al.
patent: 4436824 (1984-03-01), Bishop
patent: 5043260 (1991-08-01), Jauregui
patent: 5290684 (1994-03-01), Kelly
patent: 5486335 (1996-01-01), Wilding et al.
patent: 5496697 (1996-03-01), Parce et al.
patent: 5498392 (1996-03-01), Wilding et al.
patent: 5587128 (1996-12-01), Wilding et al.
patent: 5612188 (1997-03-01), Shuler et al.
patent: 5637469 (1997-06-01), Wilding et al.
patent: 5726026 (1998-03-01), Wilding et al.
patent: 5744366 (1998-04-01), Kricka et al.
patent: 5820769 (1998-10-01), Chou
patent: 5900160 (1999-05-01), Whitesides et al.
patent: 5906828 (1999-05-01), Cima et al.
patent: 6054277 (2000-04-01), Furcht et al.
patent: 6133030 (2000-10-01), Bhatia et al.
patent: 6197575 (2001-03-01), Griffith et al.
patent: 6329195 (2001-12-01), Pfaller
patent: 6562616 (2003-05-01), Toner et al.
patent: 6653124 (2003-11-01), Freeman
patent: 7288405 (2007-10-01), Shuler et al.
patent: 2003/0082795 (2003-05-01), Shuler et al.
patent: 2003/0096405 (2003-05-01), Takayama et al.
patent: 2007/0015273 (2007-01-01), Shuler et al.
patent: 2007/0015274 (2007-01-01), Shuler et al.
patent: 2007/0015275 (2007-01-01), Shuler et al.
patent: 2007/0020693 (2007-01-01), Shuler et al.
patent: 2007/0026519 (2007-02-01), Shuler et al.
patent: 2007/0037273 (2007-02-01), Shuler et al.
patent: 2007/0037275 (2007-02-01), Shuler et al.
patent: 2007/0037277 (2007-02-01), Shuler et al.
patent: 2007/0048727 (2007-03-01), Shuler et al.
patent: 2008/0064088 (2008-03-01), Shuler et al.
patent: 2008/0166794 (2008-07-01), Shuler et al.
patent: 2008/0166795 (2008-07-01), Shuler et al.
patent: 0539383 (1996-09-01), None
patent: 0637996 (1997-07-01), None
patent: 0823483 (1998-02-01), None
patent: 0637997 (1998-07-01), None
patent: 2786783 (2000-06-01), None
patent: 4-152885 (1992-05-01), None
patent: WO 93/11498 (1993-06-01), None
patent: WO 99/47922 (1999-09-01), None
Ausubel, et al. Current Protocols in Molecular Biology. eds. John Wiley & Sons New York NY. 2000 (Table of Contents only).
Ball, et al. CMATRIX: Software for Physiologically Based Pharmacokinetic Modeling Using a Symbolic Matrix Representation System. Comput. Biol. Med. 1994;24(4):269-276.
Buckpitt, et al. Hepatic and Pulmonary Microsomal Metabolism of Napthalene to Glutathions Adducts: Factors Affecting the Relative Rates of Conjugate Formation. J. Pharmacol. Exp. Ther. 1984; 231(2):291-300.
Cornell Chronicle. Impact of biotechnology examined at symposium. Available at http://www.news.cornell.edu/chronicle/99/9.23.99/biotech—symp.html. Accessed Nov. 7, 2006. (1 page).
Delraso, N.J. In Vitro Methodologies for Enhanced Toxicity Testing. Toxicol. Lett. 1993; 68:91-99.
Funding Proposal No. 96-OLMSA-03-112 to NASA for “Enhancement of cell function in culture by controlled aggregation under microgravity conditions.” Approximately 1996.
Funding Proposal No. 9876771 to National Science Foundation for “The nanobiotechnology Center.” Approximately 1998.
Funding Proposal to Cornell CAT-biotech grant for “Development of a cell culture analog device for testing chemical toxicity.” Approximately 1998.
Funding Proposal to National Science Foundation-NBTC for “Microanalysis of biomolecules.” Approximately 2000.
Ghanem, et al. Characterization of a perfusion reactor utilizing mammalian cells on microcarrier beads. Biotechnol Prog. 2000; 16(3):471-9.
Ghanem, et al. Combining cell culture analogue reactor designs and PBPK models to probe mechanisms of naphthalene toxicity. Biotechnol Prog. 2000; 16(3):334-45.
Goodman and Gilman. The Pharmacological Basis of Therapeutics. McGraw-Hill, New York, York, Ninth edition, under sections: Drugs Acting at Synaptic and Neuroeffector Junctional Sites; Drugs Acting on the Central Nervous System; Aytacoids: Drug Therapy of Inflammation; Water, Salts and Ions; Drugs Affecting Renal Function and Electrolyte Metabolism; Cardiovascular Drugs; Drugs Affecting Gastrointestinal Function; Drugs Affecting Uterine Motility; Chemotherapy of Parasitic Infections; Chemotherapy of Microbial Diseases; Chemotherapy of Neoplastic Diseases; Drugs Used for Immunosuppresssion, Drugs Acting on Blood-Forming Organs; Hormones and Hormone Antagonists; Vitamins; Dermatology; Toxicology. 1996.
Haddad, et al. A Methodology for Solving Physiologically Based Pharmacokinetic Models Without the Use of Simulation Software. Toxicol. Lett. 1996; 85(2):113-126.
Haies, et al. Morphometric Study of Rat Lung Cells. Am. Rev. Respir. Dis. 1981; 123:533-541.
Hoang, et al. Physiologically Based Pharmacokinetic Models: Mathematical Fundamentals and Simulation Implementations. Toxicol. Lett. 1995; 79(1-3):99-106.
Hodgson, et al. ADMET-Turning Chemicals into Drugs. Nat. Biotech. 2001; 19:722-726.
Hwang, et al. Ferredoxin Reductase Affect p53-Dependent, 5-Fluorouracil-Induced Apoptosis in Colorectal Cancer Cells. Nat. Med. 2001; 7(10):1111-1117.
Ikeda, et al. Bioactivation of Tegafur to 5-Fluorouracil Is Catalyzed by Cytochrome P-450 2A6 in Human Liver Microsomes in Vitro. Clin. Cancer Res. 2000; 6:4409-4415.
Information related to a presentation for “An ‘Animal’ on a Chip: Preclinical Evaluation of Pharmaceutical” given at the Biochemical Engineering XI: Molecular Diversity in Bioprocessing Conference on or about Jul. 25, 1999.
Jones, et al. Glowing Jellyfish, Luminescence and a Molecule Called Coelenterazine. Trends Biotechnol. 1999; 17(12):477-481.
Knaak, et al. Development of Partition Coefficients,VmaxandKmValues, and Allometric Relationships. Toxicol. Lett. 1995; 79(1-3):87-98.
Koebe, et al. In vitro toxicology in hepatocyte bioreactors-extracellular acidification rate (EAR) in a target cell line indicates hepato-activated transformation of substrates. Toxicology. 2000; 154(1-3):31-44.
Komatsu, et al. Roles of Cytochromes P450 1A2, 2A6, and 2C8 in 5-Fluorouracil Formation from Tegafur, an Anticancer Prodrug, in Human Liver Microsomes. Drug Met. Disp. 2000; 28(12):1457-1463.
Li, et al. Single-Step Procedure for Labeling DNA Strand breaks with Fluorescein- or BODIPY-Conjugated Deoxynucleotides: Detection of Apoptosis and Bromodeoxyuridine Incorporation. Cytometry. 1995; 20:172-180.
Matsuda, et al. Microfabricated Surface Designs for Cell Culture and Diagnosis. ASAIO Journal. 1994; pp. M594-M597.
News From COTABA: 14th Biotechnology Symposium. News From the Cornell Office of Economic Development. Issue 10. Sep. 1999.
Poulin, et al. A Priori Prediction of Tissue: Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically-Based Pharmacokinetic Models in Drugs Discovery. J. Pharm. Sci. 2000; 89(1):16-35.
Powers, et al. A microfabricated array bioreactor for perfused 3D liver culture. Biotechnol Bioeng. 2002; 78(3):257-69.
Powers, et al. Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor. Tissue Eng. 2002; 8(3):499-513.
Rodriguez-Antona, et al. Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies. Arch. Biochem. Biophys. 2000; 376(1):109-116.
Schwartz, J. 20 Years Young and Getting Smaller. Cornell Engineering Magazine. vol. 4, No. 3. Published Fall 1998. Available at http://132.236.67.210/engrMagazine/magazine.cfm?issue=FALL1998&page—number=1 §ion=feature4 and http://132.236.67.210/engrMagazine/magazine.cfm?section=feature4&page—number=2 &issue=FALL1998. Accessed Mar. 27, 2007. (Total 5 pages).
Shuler, et al. An “animal” on a chip: Preclinical evaluation of pharmaceuticals. United Engineering Foundation Inc. Jul. 1999.
Shuler, M. L. Presnetated Papers. Available at http://webserver.cheme.cornell.edu/peopleevents/faculty/shuler/presented%20papers.html. Accessed Nov. 13, 2006. (pp. 1-14).
Slob, et al. Structural Identifiability of PBPK Models: Practical Consequences for Modeling Strategies and Study Desi

Affiliated with

Also associated with

Rating

Devices and methods for pharmacokinetic-based cell culture... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Devices and methods for pharmacokinetic-based cell culture..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Devices and methods for pharmacokinetic-based cell culture... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4276413