Devices and methods for pharmacokinetic-based cell culture...

Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing

Reexamination Certificate

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C435S373000, C435S293100, C435S294100

Reexamination Certificate

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10133977

ABSTRACT:
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

REFERENCES:
patent: 3941662 (1976-03-01), Munder et al.
patent: 3948732 (1976-04-01), Haddad et al.
patent: 5290684 (1994-03-01), Kelly
patent: 5486335 (1996-01-01), Wilding et al.
patent: 5496697 (1996-03-01), Parce et al.
patent: 5498392 (1996-03-01), Wilding et al.
patent: 5587128 (1996-12-01), Wilding et al.
patent: 5612188 (1997-03-01), Shuler et al.
patent: 5637469 (1997-06-01), Wilding et al.
patent: 5726026 (1998-03-01), Wilding et al.
patent: 5744366 (1998-04-01), Kricka et al.
patent: 5820769 (1998-10-01), Chou
patent: 5900160 (1999-05-01), Whitesides et al.
patent: 6054277 (2000-04-01), Furcht et al.
patent: 6197575 (2001-03-01), Griffith et al.
patent: 6562616 (2003-05-01), Toner et al.
patent: 6653124 (2003-11-01), Freeman
patent: 0 539 383 (1991-03-01), None
patent: 0 637 996 (1993-04-01), None
patent: 0 637 997 (1993-04-01), None
patent: 0 823 483 (1997-01-01), None
patent: 2 786 783 (2000-06-01), None
patent: 4-152885 (1992-05-01), None
patent: WO 93/11498 (1993-06-01), None
patent: WO 99/47922 (1999-09-01), None
Michael L. Shuler-Papers. “Presented Papers”, pp. 1-14, Nov. 13, 2006, web address: http://webserver.cheme.cornell.edu/peopleevents/faculty/shuler/presented%20papers.html.
Impact of biotechnology examined at symposium, web page drawn to a symposium held on Oct. 11, 1999, web address: http://www.news.cornell.edu/Chronicle/99/9.23.99/biotech—symp.html.
Koebe et al., “In vitro Toxicology in Hepatocyte Bioreactors-Extracellular Acidification Rate (EAR) in a Target Cell Line Indicates Hepato-Activated Transformation of Substrates,”Toxicology, 154:31-44 (2000).
Slob et al., “Structural Idendifiability of PBPK Models: Practical Consequences for Modeling Strategies and Study Designs,”Crit. Rev. Toxicol., 27(2):261-272 (1997).
Haddad et al., “A Methodology for Solving Physiologically Based Pharmacokinetic Models Without the Use of Simulation Software,”Toxicol. Lett., 85(2):113-126 (1996).
Hoang et al., “Physiologically Based Pharmaokinetic Models: Mathematical Fundamentals and Simulation Implementations,”Toxicol. Lett., 79(1-3):99-106 (1995).
Knaak et al., “Development of Partition Coefficients, Vmaxand KmValues, and Allometric Relationships,”Toxicol. Lett., 79(1-3):87-98 (1995).
Ball et al., “CMATRIX: Software for Physiologically Based Pharmacokinetic Modeling Using a Symbolic Matrix Representation System,”Comput. Biol. Med., 24(4):269-276, 1994.
Buckpitt et al., “Hepatic and Pulmonary Microsomal Metabolism of Napthalene to Glutathions Adducts: Factors Affecting the Relative Rates of Conjugate Formation,”J. Pharmacol. Exp. Ther., 231(2):291-300 (1984).
DelRaso, N.J., “In Vitro Methodologies for Enhanced Toxicity Testing,”Toxicol. Lett., 68:91-99 (1993).
Haies et al., “Morphometric Study of Rat Lung Cells,”Am. Rev. Respir. Dis., 123:533-541 (1981).
Ausubel et al., “Current Protocols in Molecular Biology,” eds, John Wiley & Sons, New York, NY (2000), table of contents only.
Goodman and Gilman, “The Pharmacological Basis of Therapeutics,” McGraw-Hill, New York, New York, Ninth edition, under sections: Drugs Acting at Synaptic and Neuroeffector Junctional Sites; Drugs Acting on the Central Nervous System; Aytacoids: Drug Therapy of Inflammation; Water, Salts and Ions; Drugs Affecting Renal Function and Electrolyte Metabolism; Cardiovascular Drugs; Drugs Affecting Gastrointestinal Function; Drugs Affecting Uterine Motility; Chemotherapy of Parasitic Infections; Chemotherapy of Microbial Diseases; Chemotherapy of Neoplastic Diseases; Drugs Used for Immunosuppression, Drugs Acting on Blood-Forming Organs; Hormones and Hormone Antagnosists; Vitamins; Dermatology; Toxicology, (1996), table of contents only.
Somani, S.M. (Ed.), “Chemical Warfare Agents,” Academic Press, New York (1992), table of contents only.
Jones et al., “Glowing Jellyfish, Luminescence and a Molecule Called Coelenterazine,”Trends Biotechnol., 17(12):477-481 (1999).
Rodriguez-Antona et al., “Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies,”Arch. Biochem. Biophys., 376(1):109-116 (2000).
Smyth et al., “Markers of Apoptosis: Methods for Elucidating the Mechanism of Apoptotic Cell Death from the Nervous System,”Biotechniques, 32(3):648-665 (2000).
Wronski et al., “Two-Color, Fluorescence-Based Microplate Assay for Apoptosis Detection,”Biotechniques, 32(3):666-668 (2002).
Williamson et al., “Phosphatidylserine Exposure and Phagocytosis of Apoptotic Cells,”Methods in Cell Biology, 66:339-364 (2001).
Li et al., “Single-Step Procedure for Labeling DNA Strand Breaks with Fluorescein- or BODIPY-Conjugated Deoxynucleotides: Detection of Apoptosis and Bromodeoxyuridine Incorporation,”Cytometry, 20:172-180 (1995).
Ikeda et al., “Bioactivation of Tegafur to 5-Fluorouracil Is Catalyzed by Cytochrome P-450 2A6 in Human Liver Microsomes in Vitro,”Clin. Cancer Res., 6:4409-4415 (2000).
Komatsu et al., “Rules of Cytochromes P450 1A2, 2A6, and 2C8 in 5-Fluorouracil Formation from Tegafur, an Anticancer Prodrug, in Human Liver Microsomes,”Drug. Met. Disp., 28(12):1457-1463 (2000).
Yamazaki et al., “Rat Cytochrome P450 1A and 3A Enzymes Involved in Bioactivation of Tegafur to 5-Fluorouracil and Autoinduced by Tegafur in Liver Microsomes,”Drug Met. Disp., 29(6):794-797 (2000).
Hwang et al., “Ferredoxin Reductase Affects p53-Dependent, 5-Fluorouracil-Induced Apoptosis in Colorectal Cancer Cells,”Nat. Med., 7(10):1111-1117 (2001).
Hodgson et al., “ADMET-Turning Chemicals into Drugs,”Nat. Biotech., 19:722-726 (2001).
Poulin et al., “APrioriPrediction of Tissue: Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically-Based Pharmacokinetic Models in Drugs Discovery,”J. Pharm. Sci., 89(1):16-35 (2000).
Matsuda et al., “Microfabricated Surface Designs for Cell Cultures and Diagnosis,”ASAIO Journal, pp. M594-M597 (1994).
Sweeney, L.M., et al., “A Cell Culture Analogue of Rodent Physiology: Application to Naphthalene Toxicology”,Toxicology in Vitro, vol. 9, No. 3, (Jun. 1995), pp. 307-316.
Sweeney, et al.,A Cell Culture Analogue of Rodent Physiology: Application to Naphthalene Toxicology, Toxic. in Vitro, vol. 9, No. 3, pp. 307-316, 1995.
Schuler, et al.,An “Animal” on a Chip: Preclinical Evaluation of Pharmaceuticals, United Engineering Foundation Inc., Jul. 1999.
Ghanem, et al.,Combining Cell Culture Analogue Reactor Designs and PBPK Models to Probe Mechanisms of Naphthalene Toxicity, Biotechnol. Prog. 2000, 16, pp. 334-345.
Ghanem, et al.,Characterization of a Perfusion Reactor Utililzing Mammalian Cells on Microcarrier Beads, Biotechnol. Prog. 2000, 16, pp. 471-479.
Powers, et al.,A Microfabricated Array Bioreactor for Perfused 3D Liver Culture, Biotechnology and Bioengineering, vol. 78, No. 3, May 5, 2002.
Powers, et al.,Functional Behavior of Primary Rat Liver Cells in a Three-Dimensional Perfused Microarray Bioreactor, Tissue Engineering, vol. 8, No. 3, 2002.
Information related to a presentation for “An ‘Animal’ On A Chip: Preclinical Evaluation Of Pharmaceutical Evaluation Of Pharmaceuticals” given at the Biochemical Engineering XI: Molecular Diversity in Bioprocessing Conference on or about Jul. 25, 1999.
Funding Proposal No. 96-OLMSA-03-112 to NASA for “Enhancement of cell function in culture by controlled aggregation under microgravity conditions.” Approximately 1996.
Funding Proposal to Cornell CAT-biotech grant for “Development of a cell culture analog device for testing chemical toxicity.” Approximately 1998.
Funding Proposal No. 9876771 to National Science Foundation for &#

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