Devices and methods comprising an HBcAg from hepatitis B virus

Details Devices and methods comprising an HBcAg from hepatitis B virus Devices and methods comprising an HBcAg from hepatitis B virus

1998-07-14

2000-11-28

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 5, 435 4, 435 792, 536 2372, G01N 3353, G01N 33537, G01N 33543, C12Q 100, C12Q 170

Patent

active

061533920

ABSTRACT:
A complex comprised of the HBcAg and an albumin or an unprocessed structural protein from a positive stranded RNA virus. Pursuant to such complexing, the antigenicity of the HBcAg is enhanced when compared to HBcAg alone, in terms of both or either affinity or specificity. This complexed HBcAg can be recognized by the immune system, which produces antibodies that have a high specificity and affinity for the complexed HBcAg, although such antibodies typically do also bind the uncomplexed antigen to a lower specificity and affinity. Also, methods and devices using the same.

REFERENCES:
patent: 5376557 (1994-12-01), Schmitt
Yamaki et al.; Circular dichroism and biochemical properties of the hepatitis B viru core antigen; Biocemica of Biophysica Acta; vol. 706; pp. 165-173, 1982.

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