Device to promote drug-induced nerve regeneration

Details Device to promote drug-induced nerve regeneration Device to promote drug-induced nerve regeneration

1994-01-26

1997-08-12

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 9321, 424 937, 424423, 424426, 6048901, 606152, A61B 1708, A61K 900, A61K 3818, A61L 3100

Patent

active

056566050

ABSTRACT:
The invention relates generally to a system for promoting regeneration of a damaged nerve. In particular, the invention comprises: (1) a guide tube constructed to be attached to the damaged nerve; (2) guiding filaments disposed within the guide tube; and, (3) a therapeutic composition enclosed by the guide tube. Both the guide tube and the guiding filaments are composed of biologically compatible materials, while the therapeutic composition contains a nerve-growth-stimulating agent dispersed in a matrix-forming material. During treatment, the guide tube is inserted between the ends of lesioned nerves, resulting in the stimulation of axon growth.

REFERENCES:
patent: 4778467 (1988-10-01), Stensaas et al.
patent: 4878913 (1989-11-01), Aebischer
patent: 5092871 (1992-03-01), Aebischer et al.
patent: 5147399 (1992-09-01), Dellon et al.
patent: 5292802 (1994-03-01), Rhee et al.
Experimental Neurology, vol. 107, No. 1, issued Jan. 1990, Kosaka, "Enhancement of Rat Peripheral Nerve Regeneration . . . ", pp. 69-77.
Experimental Neurology, vol. 95, issued 1987, Madison et al, "Peripheral Nerve Regeneration with Entubulation Repair . . . ", pp. 378-390.
Journal of Neurosurgery, vol. III, No. 1, issued Jan. 1946, Weiss et al, "Guides For Nerve Regeneration Across Gaps", pp. 375-389.
Aebischer et al., "Basic Fibroblast Growth Factor Released From Synthetic Guidance Channels Facilitates Peripheral Nerve Regeneration Across Long Nerve Gaps" J. Neuroscience Res., 23:282-289, 1989.
Alexander et al., "Further Experiments on Bridging of Long Nerve Gaps in Monkeys" Proc. Soc. Exp. Biol. Med., 68: 380-382, 1948.
Chen et al., "Facial Nerve Regeneration in the Silicone Chamber: The Influence of Nerve Growth Factor" Experimental Neurology, 103: 52-60, 1989.
Lundborg et al., "Regeneration of peripheral nerve through a preformed tissue space. Preliminary observations on the reorganization of regenerating nerve fibres & perineurium" Brain Research, 178: 573-576, 1979.
Lundborg et al., "Nerve regeneration through preformed pseudosynovial tubes" J. Hand Surgery, 5: 35-38, 1980.
Rich et al., "Nerve Growth Factor Enhances Regeneration through Silicone Chambers" Experimental Neurology, 105: 162-170, 1989.
Sjoberg et al., "Insulin-like growth factor (IGF-1) as a stimulator of regeneration in the freeze-injured rat sciatic nerve" Brain Research, 485: 102-108, 1989.
Stopford, "The Treatment of Large Defects in Peripheral Nerve Injuries" The Lancelet, CXCIX: 1296-1297, 1920.
Valentini et al., "Collagen-and Laminin-Containing Gels Impede Peripheral Nerve Regeneration through Semipermeable Nerve Guidance Channels" Experimental Neurology, 98: 350-356, 1987.

Affiliated with

Also associated with

Rating

Device to promote drug-induced nerve regeneration does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Device to promote drug-induced nerve regeneration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Device to promote drug-induced nerve regeneration will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-160587