Device for the iontophoretic administration of bisphosphonates

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607 51, A61N 130

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057358109

ABSTRACT:
The present invention relates to a method and device for the iontophoretic delivery of a therapeutic dose range of bisphosphonate to be delivered to a patient over a period of lime to prevent the onset for advancement of osteoporosis and other metabolic bone diseases for a selected period of time.

REFERENCES:
patent: 5376107 (1994-12-01), Inagi et al.
Landman, J.O., et al., "Recovery of Serum Calcium Concentrations following Acute Hypocalcemia in Patients with Osteoporosis . . . " J. Clin. Endocrin. Met. 80(2)524-8(1995).
Dawson-Hughes, B. et al. "A controlled trial of the effect of calcium supplementation on bone density . . . " New Eng. J. Med. Sep. 27, 1990, 323(13)878-883.
Watts, N.B., Blevins, L.S.Jr., "Endocrinology" JAMA Jun. 19, 1996 275(23) 1806-1807.
Pak, C.Y.C.,et al., "Treatment of Postmenopausal Osteoporosis with Slow Release Sodium Fluoride," Annals of Internal Medicine, Sep. 15, 1995,123(6)401-8.
Storm, Thomas, et al. Effect of Intermittent Cyclical Etidionate Therapy on Bone Mass . . . , 322 New Eng. Jnl. Med. 1265 (1990).

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