Device for the controlled release of active substances

Details Device for the controlled release of active substances Device for the controlled release of active substances

1994-12-02

1998-12-29

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424474, 514964, 71 6413, A61K 924, A61K 928

Patent

active

058537600

ABSTRACT:
A device for the controlled release of active substances in liquid media from an active substance-containing matrix exhibiting active substance releasing-surfaces has, the active substance releasing surfaces of the matrix covered, at least partially, by an erodible mass of solids; the thickness of the erodible mass across its extent on the active substance releasing-areas is determined by gradients.

REFERENCES:
patent: 2798024 (1957-07-01), Zapapas et al.
patent: 3383283 (1968-05-01), Brindamour
patent: 3625214 (1971-12-01), Higuchi
patent: 4814182 (1989-03-01), Graham et al.
patent: 5284659 (1994-02-01), Cherukuri
patent: 5391378 (1995-02-01), Sanderson
patent: 5422123 (1995-06-01), Conte et al.
patent: 5601843 (1997-02-01), Gimet et al.
Theeuwes, Pharm. Int. 5, p. 293, 1984.
Higuchi, J. Pharm. Sci. 50, p. 874, 1961.

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