Device for solid phase sequencing of nucleic acid fragments

Details Device for solid phase sequencing of nucleic acid fragments Device for solid phase sequencing of nucleic acid fragments

1987-11-12

1989-11-21

Price, Carl D.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

422 65, 422 66, 422 73, 422116, 422102, 422104, 422131, 435300, 435301, C12M 116, B01L 300, B01L 900

Patent

active

048821276

ABSTRACT:
A device for solid phase sequencing of nucleic acid segments comprises a plurality of sequencing blocks for storaging and processing n nucleic acid fragments immobilized on carrier segments or in homogenous phase during a sequencing process, each of a sample dosing device for immobilizing n labeled nucleic acid samples from the sequencing blocks onto areas of a carrier matrix in a simultaneous fashion and including a capillary holder and a plurality of capillaries corresponding to the number n of different nucleic acid samples to be sequences and arranged according to the distribution of the reaction vessels with a distance between capillary orifices from the capillary holder greater than a depth of the reaction vessels, a plurality of carrier holders for fixing carrier matrices in a predetermined position during the immobilization of the nucleic acid samples with the sample dosing device and each having a recess corresponding to respective dimensions of the carrier matrix and a plurality of bores with a number and distribution pattern corresponding to those of the reaction vessels and with a diameter which is somewhat larger than a diameter of the capillary, a punch for simultaneous punching of n immobilized and chemically modified nucleic acid samples as individual carrier segments out of the carrier matrix into the sequencing blocks and including a punching plate and a plurality of punching pins with a number and distribution pattern which also corresponds to those of the reaction vessels.

REFERENCES:
patent: 3497320 (1970-02-01), Blackburn et al.
patent: 3770380 (1973-11-01), Smith
patent: 3888113 (1975-06-01), Miraneda
patent: 4058370 (1977-11-01), Suovaniemi
patent: 4155711 (1979-05-01), Zelagin et al.
patent: 4341735 (1982-07-01), Seifried
patent: 4349510 (1982-09-01), Kolehmainen et al.
patent: 4446104 (1984-05-01), Hammerling et al.
patent: 4568520 (1986-02-01), Ackermann et al.

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