Device for removing leukocytes from blood

Liquid purification or separation – Casing divided by membrane into sections having inlet – Cylindrical membrane

Reexamination Certificate

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Details

C210S321890, C210S500230, C210S500210, C210S321620

Reexamination Certificate

active

07985337

ABSTRACT:
A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2of fiber surface.

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patent: 5026365 (1991-06-01), Rossini et al.
patent: 5143312 (1992-09-01), Baurmeister
patent: 6498007 (2002-12-01), Adachi et al.
patent: 2008/0203024 (2008-08-01), Lemke et al.
patent: 2009/0060890 (2009-03-01), Humes et al.
patent: 0285812 (1988-10-01), None
patent: 0732141 (1996-09-01), None
patent: WO 95/18665 (1995-07-01), None
patent: WO 2007/057065 (2007-05-01), None

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