Device for release of a substance

Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...

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Details

604 85, 604 92, 137268, A61M 3100, A61M 3700, E03B 1100

Patent

active

052017052

DESCRIPTION:

BRIEF SUMMARY
The present invention is related to a device intended to be used in parenteral liquid administration to a patient, whereby one during such administration desires to release a substance, such as a drug, to the liquid.
A device by which drugs can be supplied to a parenteral liquid flow is shown by EP-B-0059694. Modified such devices are shown by EP-A-0077604, EP 85850141.4, EP-A-0100296 and WO 86/03416. A device for connection into a flow of infusion liquid, where the liquid by means of a valve can be led either via a vial for a drug to the patient or bypassing said vial, is shown by EP-A-0163387. A similar device having three operative valve positions, one for bypass of the liquid, one for dilution of a drug and one for emptying of a drug solution in an administration system, is shown by U.S. Pat. No. 4,534,758. The two lastmentioned systems require that a liquid preparation ready for administration is formed in the vial before the valve is put in an administration position.
An object of the present invention is to achieve a device where a container for a dry drug preparation exchangeably can be connected to a liquid administration system, whereupon the liquid can be deviated and brought into contact with the drug thus that the drug is added to the liquid during administration of the liquid. A further object is to achieve a device where inadvertent deviation of the liquid is avoided when no drug container is connected.
Thus the device of the invention is a device for release of a substance from a solid preparation thereof to a flowing liquid during simultaneous parenteral administration of the liquid to a patient, which device comprises a connector connectable into a system for parenteral administration of the liquid, and having an inlet and outlet with a valve device which comprises a mobile valve core having a bypass position providing for direct liquid flow from the inlet to the outlet of the connector and a working position providing for liquid flow from the inlet of the connector into a releasable container for the solid preparation. The device of an invention is characterized in that the valve core has an outlet means and a separate inlet means simultaneously connectable to an inlet means and a separate outlet means respectively on the releasable container, the releasable container further having therein means for conducting the liquid from the inlet thereof to a space where it will contact the solid preparation, and further to the outlet of the releasable container, and via the valve core in a flow path to the outlet of the connector.
In a preferred embodiment of the invention the releasable container is a manoeuvre device for the valve core and the valve core has no other manoeuvre devices. Thus, when the valve core is rotatable in the valve device the releasable container may function as a handle gripping the end of the valve core by means of its inlet and outlet means. Inadvertent deviation of the liquid when no container is connected will be avoided by the invention in particular by this embodiment. Thus risks of liquid spillage and air suction into the administration system are reduced.
Preferably the outlet and inlet of the valve core are connectable to the inlet and outlet of the releasable container by socket means, and preferably the socket means are tapered sockets fitting in tapered holes, and preferably the tapered sockets are the outlet means and inlet means of the releasable container and that the tapered holes are the inlet means and outlet means on the valve core.
In a specially preferred embodiment of the device a filter is arranged within the connector in the flow path from the valve in the working position to the outlet of the connector. Suitably the flow of liquid in the bypass position of the valve has dual flow paths to the outlet either through the filter or via the valve core.
Use of a device as described for release of a substance from a solid preparation thereof to a liquid during simultaneous parenteral administration ministration of the liquid to a patient is a further emb

REFERENCES:
patent: 2345275 (1944-03-01), Marvin
patent: 3003518 (1961-10-01), Tisdale
patent: 3051174 (1962-08-01), Mandell
patent: 4465471 (1984-08-01), Harris et al.
patent: 4474574 (1984-10-01), Wolfe et al.
patent: 4534758 (1985-08-01), Akers et al.
patent: 4581014 (1986-04-01), Millerd et al.
patent: 4671311 (1987-06-01), Hepperle et al.
patent: 5005604 (1991-04-01), Aslanian

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