Device for purifying solutions containing proteins and use of th

Liquid purification or separation – Processes – Ion exchange or selective sorption

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210645, 21050024, 210504, 502403, B01J 2000

Patent

active

060902922

ABSTRACT:
The invention relates to a device for purifying protein-containing solutions such as blood, blood plasma or cell culture media, where a biocompatible support material made of a plastic material, selected from the group of polyacrylates, polymethacrylates, polysulfone and polyether sulfone, is coated with albumin, which is bound by peptide binding. In addition, the invention relates to a method of producing the support material according to this invention and the use of the device.

REFERENCES:
patent: 4411832 (1983-10-01), Cuatrecasas et al.
patent: 5476715 (1995-12-01), Otto
Chemical Abstracts, vol. 93, 1980, p. 36.
Plotz, et al., "Removing Substances From Blood By Affinity Chromatography", Journal of Clinical Investigation, vol. 53, Mar. 1974, pp. 778-785.
Remillard et al., "Quantitation of Endotoxin In Products Using The Lal Kinetic Turbidimetric Assay" 1987, pp. 197-210.
Rosenbaum et al., "Current Status of Hemoperfusion In Toxicology", 1980, Clin. Toxicology, 17:493.
Shimizu et al., Enzymatic Determination of Serum-Free Fatty Acids:A Colorimetric Method, Analytical Biochemistry, vol. 107, No. 1, Sep. 1980, pp. 193-198.

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