Device for maintaining and growing human stem and/or hematopoiet

Details Device for maintaining and growing human stem and/or hematopoiet Device for maintaining and growing human stem and/or hematopoiet

1994-01-06

1995-10-17

Beisner, William H.

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

4352931, 4352932, 4352971, 4352972, C12M 300, C12M 304

Patent

active

054590698

ABSTRACT:
Devices are provided for the growth of human stem and/or hematopoietic cells in culture. Bioreactors are provided in which diverse cell types are simultaneously-cultured in the presence of appropriate levels of nutrients and growth factors substantially continuously maintained in the bioreactor while removing undesirable metabolic products. This simultaneous culture of multiple cell types successfully reconstructs hematopoietic tissue ex vivo. Optionally, at least one growth factor is provided through excretion by transfected stromal cells, particularly heterologous cells. The stromal cells and hematopoietic cells are maintained separately and both the adherent and non-adherent cells are harvested.

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